Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) (Middle Region) Peptide
WNT1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all WNT1 products
- WNT1 (Wingless-Type MMTV Integration Site Family, Member 1 (WNT1))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-WNT1 antibody (Catalog #: ARP32122_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- WNT1 (Wingless-Type MMTV Integration Site Family, Member 1 (WNT1))
- Synonyms
- Xint-1 Peptide, Xwnt1 Peptide, int-1 Peptide, int1 Peptide, wnt-1 Peptide, wnt1-a Peptide, Int-1 Peptide, Wnt-1 Peptide, sw Peptide, swaying Peptide, BMND16 Peptide, INT1 Peptide, OI15 Peptide, Int1 Peptide, WNT-1 Peptide, sb:eu647 Peptide, zgc:194464 Peptide, zgc:194478 Peptide, WNT1 Peptide, Wnt family member 1 Peptide, Wnt family member 1 L homeolog Peptide, wingless-type MMTV integration site family, member 1 Peptide, WNT1 Peptide, wnt1.L Peptide, Wnt1 Peptide, wnt1 Peptide
- Background
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WNT1 is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT1 is very conserved in evolution, and it is known to be 98 % identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. WNT1 was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. WNT1 is clustered with another family member, WNT10B, in the chromosome 12q13 region.The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98 % identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: INT1
Protein Interaction Partner: FZD8,RYK,FZD8,FZD9,LRP5,LRP6,PORCN,RYK,SFRP1,SFRP2,WNT3A,FZD8,LRP6,SFRP1
Protein Size: 370 - Molecular Weight
- 38 kDa
- Gene ID
- 7471
- NCBI Accession
- NM_005430, NP_005421
- UniProt
- P04628
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