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Browse our anti-DEPTOR (DEPTOR) Antibodies

Full name:
anti-DEP Domain Containing MTOR-Interacting Protein Antibodies (DEPTOR)
On are 64 DEP Domain Containing MTOR-Interacting Protein (DEPTOR) Antibodies from 12 different suppliers available. Additionally we are shipping DEPTOR Proteins (4) and DEPTOR Kits (3) and many more products for this protein. A total of 77 DEPTOR products are currently listed.
4731402B04Rik, 9130412E02Rik, D15Ertd336e, D15Ertd597e, DEP.6, Depdc6, Depdc6-001, Depdc6-002, mKIAA4200, R75183, RAPGEF4, RGD1561030
list all antibodies Gene Name GeneID UniProt
DEPTOR 64798 Q8TB45
DEPTOR 97998 Q570Y9
DEPTOR 314979  

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anti-Human DEPTOR Antibodies:

anti-Mouse (Murine) DEPTOR Antibodies:

anti-Rat (Rattus) DEPTOR Antibodies:

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Top referenced anti-DEPTOR Antibodies

  1. Human Polyclonal DEPTOR Primary Antibody for ICC, IF - ABIN4304935 : Jegg, Ward, Iorns, Hoe, Zhou, Liu, Singh, Landgraf, Pegram: PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells. in Breast cancer research and treatment 2012 (PubMed)
    Show all 6 references for ABIN4304935

  2. Human Polyclonal DEPTOR Primary Antibody for IF (p), IHC (p) - ABIN1387597 : Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma. in OncoTargets and therapy 2015 (PubMed)

More Antibodies against DEPTOR Interaction Partners

Human DEP Domain Containing MTOR-Interacting Protein (DEPTOR) interaction partners

  1. Cul1 (show CUL1 Antibodies) promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.

  2. Propose regulation of placental SNAT2 (show SLC38A2 Antibodies)/LAT1 (show LAT Antibodies) ubiquitination by mTORC1 and Nedd4-2 (show NEDD4L Antibodies).

  3. Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin (show BIRC5 Antibodies) expression

  4. Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.

  5. Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.

  6. conclude that DEPTOR-related mTOR (show FRAP1 Antibodies) suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy

  7. our data provide evidence for the requirement of TGFbeta (show TGFB1 Antibodies)-activated mTORC1 only by deptor downregulation, which dominates upon the bystander mTORC2 (show CRTC2 Antibodies) activity for enhanced expression of collagen I (alpha2).

  8. In Alzheimer's disease patients the mTOR (show FRAP1 Antibodies) pathway can be overactive, leading to a dysfunction of autophagy and a lack of amyloid beta clearance so the excess of amyloid beta will cause a further decrease in DEPTOR and an increase in mTOR (show FRAP1 Antibodies) expression.

  9. Receptor CXCR4 (show CXCR4 Antibodies) signaling promotes lysosomal and ESCRT-dependent degradation of DEPTOR, an antagonist of mTORC2 (show CRTC2 Antibodies), that regulates Akt (show AKT1 Antibodies) activation and signaling.

  10. Downregulation of DEPTOR (p=0.331) in CRC (show CALR Antibodies).

Mouse (Murine) DEP Domain Containing MTOR-Interacting Protein (DEPTOR) interaction partners

  1. The present study indicates that regulation of DEPTOR/mTOR (show FRAP1 Antibodies) signaling may be an important mechanism for glutamine (show GFPT1 Antibodies) in prevention against the development of colitis-associated colorectal cancer (CAC (show SLC25A20 Antibodies)): the chemopreventive effect of dietary glutamine (show GFPT1 Antibodies) on CAC (show SLC25A20 Antibodies) is, at least in part, associated with the induction of autophagy.

  2. DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65 (show NFkBP65 Antibodies).

  3. p38gamma (show MAPK12 Antibodies) and p38delta (show MAPK1/3 Antibodies) control heart growth by modulating mTOR (show FRAP1 Antibodies) pathway through DEPTOR phosphorylation and subsequent degradation.

  4. DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR (show FRAP1 Antibodies) activity in undifferentiated embryonic stem cells

  5. DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.

  6. Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR (show FRAP1 Antibodies) kinase substrates, 4E-BP1 (show EIF4EBP1 Antibodies) and S6K1 (show RPS6KB1 Antibodies), and concomitantly increased protein synthesis.

DEPTOR Antigen Profile

Antigen Summary

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).

Alternative names and synonyms associated with DEPTOR

  • DEP domain containing MTOR-interacting protein (DEPTOR) antibody
  • DEP domain containing MTOR-interacting protein (Deptor) antibody
  • 4731402B04Rik antibody
  • 9130412E02Rik antibody
  • D15Ertd336e antibody
  • D15Ertd597e antibody
  • DEP.6 antibody
  • Depdc6 antibody
  • Depdc6-001 antibody
  • Depdc6-002 antibody
  • mKIAA4200 antibody
  • R75183 antibody
  • RAPGEF4 antibody
  • RGD1561030 antibody

Protein level used designations for DEPTOR

DEP domain containing MTOR-interacting protein , DEP domain containing 6 , DEP domain containing mTOR interacting protein , DEP domain-containing mTOR-interacting protein , DEP domain-containing protein 6 , Rap guanine nucleotide exchange factor (GEF) 4

100543973 Meleagris gallopavo
100601105 Nomascus leucogenys
64798 Homo sapiens
97998 Mus musculus
100057185 Equus caballus
314979 Rattus norvegicus
419242 Gallus gallus
482028 Canis lupus familiaris
100157658 Sus scrofa
617606 Bos taurus
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