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Our data also suggest that B56alpha functions pre-midblastula transition , inhibiting Wnt (show WNT2 Proteins) signaling on the ventral side of the embryo, and again during organogenesis, while B56gamma functions primarily post-midblastula transition
The PP2A (show PPP2R2B Proteins) B56gamma regulatory subunit controls PP2A (show PPP2R2B Proteins) substrate specificity in vivo in a manner that cannot be fully compensated for by other B56 subunits.
B56gamma1 suppressed EGF (show EGF Proteins)-induced cell migration on collagen, bound to phosphorylated-ERK (show EPHB2 Proteins), and dephosphorylated ERK (show EPHB2 Proteins).
results suggest that Ppp2r5c expression is regulated by Nrl (show NRL Proteins) during retinogenesis through direct binding to the promoter region of Ppp2r5c
the dynamic nuclear distribution of the B56gamma3 regulatory subunit controls nuclear PP2A (show PPP2R2B Proteins) activity, which regulates cell cycle controllers, such as p27 (show CDKN1B Proteins), to restrain cell cycle progression, and may be responsible for the tumor suppressor function of PP2A (show PPP2R2B Proteins)
A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression
Identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis.
PP-2A is less abundant than PP-1 in the mouse eye and appear to be highly regulated by various regulatory subunits; the genes encoding PP-1alpha/beta, PP-2Aalpha/beta, PP-2A-Aalpha/beta, and PP-2A-B alpha/beta/gamma are all differentially expressed.
PPP2R5C deletion or EGFR mutation that could be responsible for IER3/pERK overexpression was found in at least 8 cases (67% or more) of lung adenocarcinoma.
Mutations in the PP2A (show PPP2R4 Proteins) regulatory subunit B family genes PPP2R5B (show PPP2R5B Proteins), PPP2R5C and PPP2R5D (show PPP2R5D Proteins) cause human overgrowth
our data suggest that hepatic PPP2R5C represents an important factor in the functional wiring of energy metabolism and the maintenance of a metabolically healthy state.
propose that the mechanism for proliferation inhibition and increased apoptosis of K562 cells following PPP2R5C suppression may be related to the alteration of expression profiles of BRAF (show BRAF Proteins), AKT2 (show AKT2 Proteins), AKT3 (show AKT3 Proteins), NFKB2 and STAT3 (show STAT3 Proteins) genes
Differential expression of the transcripts PPP2R5C connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
KIF4A and PP2A (show PPP2R4 Proteins)-B56G and -B56E create a spatially restricted negative feedback loop counteracting Aurora B (show AURKB Proteins) in anaphase.
Data indicate that the regulatory PP2A (show PPP2R4 Proteins) subunit B56gamma mediates suppression of NF-kappaB (show NFKB1 Proteins) resulting in increased NF-kappaB (show NFKB1 Proteins) target gene expression in T cells.
Results show that mutations lost B56gamma tumor-suppressive activity by two distinct mechanisms: one is by disrupting interactions with the PP2A (show PPP2R4 Proteins) AC core and the other with B56gamma-PP2A (show PPP2R4 Proteins) substrates (p53 (show TP53 Proteins) and unknown proteins).
PPP2R5C-siRNA treatment altered gene expression profiles in malignant T cells
structural insight into the PP2A (show PPP2R4 Proteins) holoenzyme assembly and emphasizes the importance of HEAT repeat 1 in B56gamma-PP2A (show PPP2R4 Proteins) tumor-suppressive function
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
B' alpha regulatory subunit
, PP2A B subunit isoform B'-gamma
, PP2A B subunit isoform B56-gamma
, PP2A B subunit isoform PR61-gamma
, PP2A B subunit isoform R5-gamma
, protein phosphatase 2, regulatory subunit B (B56), gamma isoform
, protein phosphatase 2, regulatory subunit B', gamma isoform
, renal carcinoma antigen NY-REN-29
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
, B56/PP2A gamma
, Band 8A
, PP2A B subunit isoform B'-alpha-3
, protein phosphatase 2, regulatory subunit B, gamma isoform
, protein phosphatase 2, regulatory subunit B (B56), delta isoform
, gamma isoform of regulatory subunit B56, protein phosphatase 2A
, protein phosphatase 2, regulatory subunit B', gamma
, PP2A B subunit isoform B'-beta
, PP2A, B subunit, B' beta isoform
, PP2A, B subunit, B' gamma isoform
, PP2A, B subunit, B56 gamma isoform
, PP2A, B subunit, PR61 gamma isoform
, PP2A, B subunit, R5 gamma isoform
, protein phosphatase 2A0 B' regulatory subunit beta3 isoform
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like
, protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma
, serine/threonine-protein phosphatase 2A regulatory subunit B'' gamma subunit
, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma