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CCK1R may play a role differing from CCK2R (show CCKBR ELISA Kits) in colon carcinogenesis, nuclear CCK1R represents a potential biomarker for poor prognosis.
Study shows downregulation of CCKAR gene expression in A1/A1 genotype of gallstone disease patients as compared with control with significant variation in its expression pattern in relation to polymorphism.
Our study showed significantly higher expression of CCKAR and down regulation of CCKBR (show CCKBR ELISA Kits) in pancreatic cancer as compared to control while CCKBR (show CCKBR ELISA Kits)/GR was detected in majority of stomach cancer samples. Thus, our study suggests that CCK (show CCK ELISA Kits) and Gs receptors may have diagnostic and therapeutic implications.
The neurotransmitter cholecystokinin (CCK (show CCK ELISA Kits)), along with its receptors, CCKAR and CCKBR (show CCKBR ELISA Kits), have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort
CCK-AR polymorphism is protective against functional dyspepsia.
There is functional synergy between cholecystokinin (show CCK ELISA Kits) receptors CCKAR and CCKBR (show CCKBR ELISA Kits) in mammalian brain development.
CCK (show CCK ELISA Kits) binding modulates the contractile function of the lower esophageal sphincter through differential binding to the CCK-A receptor on the sling and clasp (show CLASRP ELISA Kits) fibers
Age related differential expression of CCKAR in GBC may suggest two possible variants of the disease in this endemic belt.
Y140A mutation within a cholesterol-binding motif results in ligand binding and activity characteristics similar to wild type CCK1R. in a high cholesterol environment
The findings suggest that variants in the CCKAR gene may influence the risk of gallbladder cancer in women.
The studies establish chronic pancreatitis as an IL-33 (show IL33 ELISA Kits)-dependent inflammation resulting from synergistic interactions between the NOD1 (show NOD1 ELISA Kits) and CCKR signaling pathways.
mice lacking CCK (show CCK ELISA Kits) receptors exhibited a functional shift from the gastrin (show GAST ELISA Kits)-CCK (show CCK ELISA Kits) pathways to the neuronal pathway in control of the ECL (show APOC4 ELISA Kits) cells and eventually the acid secretion
cellular and subcellular localization of cholecystokinin (CCK (show CCK ELISA Kits))-1 (show CCL28 ELISA Kits) receptors in the pancreas, gallbladder, and stomach
The lithogenic diet was associated with significantly lower CAV3 (show CAV3 ELISA Kits) in the liver and lower CAV3 (show CAV3 ELISA Kits) and CCKAR in the gallbladder compared with the control mice.
CCK (show CCK ELISA Kits)-8S increases [Ca(2 (show CA2 ELISA Kits)+)]i in gastric antral interstitial cells of Cajal via the CCK(1 (show CCL28 ELISA Kits)) receptor
CCK1 (show CCL28 ELISA Kits) receptor activation does not have a greater effect combination with upregulated leptin (show LEP ELISA Kits) signalling in high-fat-fed mice
Suggest role for ependymal CCK-1 (show CCL28 ELISA Kits) receptors in infant satiety-controlling mechanisms.
CCK-1 (show CCL28 ELISA Kits) and -2 receptors may function synergistically in single PaPo neurons and deletion of CCK-1 (show CCL28 ELISA Kits) receptors may facilitate CCK (show CCK ELISA Kits)-2 receptor signaling.
This study demonistrated that cholecystokinin-1 receptor relate to glucose homeostasis.
Sphincter of Oddi CCKAR expression levels increased in the cholesterol gallstone groups compared to the control group.
This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine.
, cholecystokinin B receptor
, cholecystokinin receptor
, cholecystokinin A receptor
, cholecystokinin receptor type A-like
, CCK-A receptor
, cholecystokinin receptor type A
, cholecystokinin type-A receptor
, cholecystokinin-1 receptor
, gastric cholecystokinin A receptor
, cholecystokinin 1 receptor
, Cholecystokinin receptor type A
, Cholecystokinin-1 receptor