Browse our anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antibodies

Full name:
anti-BRCA1/BRCA2-Containing Complex, Subunit 3 Antibodies (BRCC3)
On www.antibodies-online.com are 101 BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antibodies from 22 different suppliers available. Additionally we are shipping BRCA1/BRCA2-Containing Complex, Subunit 3 Proteins (14) and BRCA1/BRCA2-Containing Complex, Subunit 3 Kits (4) and many more products for this protein. A total of 126 BRCA1/BRCA2-Containing Complex, Subunit 3 products are currently listed.
Synonyms:
brcc3, brcc36, C6.1A, CXorf53, xtp1
list all antibodies Gene Name GeneID UniProt
BRCC3 79184 P46736
BRCC3 210766 P46737
BRCC3 316794 B2RYM5

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Most Popular Reactivities for anti-BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antibodies

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All available anti-BRCA1/BRCA2-Containing Complex, Subunit 3 Antibodies

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Top referenced anti-BRCA1/BRCA2-Containing Complex, Subunit 3 Antibodies

  1. Human Monoclonal BRCC3 Primary Antibody for EIA, IHC (p) - ABIN400864 : Chen, Arciero, Wang, Broccoli, Godwin: BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. in Cancer research 2006 (PubMed)
    Show all 3 references for 400864

  2. Human Polyclonal BRCC3 Primary Antibody for IHC (p), WB - ABIN318911 : Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. in Molecular cell 2003 (PubMed)
    Show all 2 references for 318911

More Antibodies against BRCA1/BRCA2-Containing Complex, Subunit 3 Interaction Partners

Human BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) interaction partners

  1. In late S/G2 (show STRN3 Antibodies) phase, the DNA damage-responsive E3 ligase RNF8 (show RNF8 Antibodies) conjugates K63-linked ubiquitin chains to tankyrase 1 (show TNKS Antibodies), while in G1 phase such ubiquitin chains are removed by BRISC, an ABRO1 (show FAM175B Antibodies)/BRCC36-containing deubiquitinase complex.

  2. findings uncover a pivotal role of BRCC36 DUB in limiting DSB processing and repair and illustrate how cells may physically couple ubiquitin recognition and metabolizing activities for fine tuning of DNA repair processes.

  3. BRCC3 may play a role in B7-H3 (show CD276 Antibodies)-induced 5-Fu resistance.

  4. BRCC3 inversely correlated with NPC (show NPC1 Antibodies) overall and relapse-free survival. Its expression was higher in radioresistant NPC (show NPC1 Antibodies) cells, where BRCC3 knockdown increased the cell survival fraction, attenuated DNA damage repair and resulted in G2/M cell cycle arrest.

  5. BRCC3 likely plays a role as tumor-associated gene in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms.

  6. KIAA0157 (show FAM175B Antibodies) allosterically activates a cognate deubiquitinating enzyme (DUB) partner and implicates super dimerization as a new regulatory mechanism underlying BRCC36 DUB activity.

  7. upregulation of BRCC3 expression is associated with glioma.

  8. these data strongly suggest that BRCC3, a deubiquitinating enzyme that is part of the cellular BRCA1 and BRISC complexes, is an important player in angiogenesis and that BRCC3 loss-of-function mutations are associated with moyamoya angiopathy.

  9. NBA1/MERIT40 (show BABAM1 Antibodies) and BRE (show BRE Antibodies) interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes

  10. scaffold proteins not only participate in the regulation of BRCC36 activity but also determine its subcellular localization and cellular functions.

Mouse (Murine) BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) interaction partners

  1. The deubiquitinating enzyme, BRCC3, is a critical regulator of NLRP3 (show NLRP3 Antibodies) activity by promoting its deubiquitination.

BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3) Antigen Profile

Antigen Summary

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

Alternative names and synonyms associated with BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3)

  • BRCA1/BRCA2-containing complex, subunit 3 (BRCC3) antibody
  • DEP domain containing 1B (depdc1b) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (LOC100339276) antibody
  • BRCA1/BRCA2-containing complex subunit 3 (brcc3) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (Brcc3) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (BRCC36) antibody
  • BRCA1/BRCA2-containing complex, subunit 3 (brcc3) antibody
  • brcc3 antibody
  • brcc36 antibody
  • C6.1A antibody
  • CXorf53 antibody
  • xtp1 antibody

Protein level used designations for BRCC3

BRCA1/BRCA2-containing complex, subunit 3 , c6.1A , BRCA1-A complex subunit BRCC36 , BRCA1/BRCA2-containing complex subunit 3 , BRCA1/BRCA2-containing complex subunit 36 , BRISC complex subunit BRCC36 , lys-63-specific deubiquitinase BRCC36 , 6.1A protein

GENE ID SPECIES
422201 Gallus gallus
465951 Pan troglodytes
612642 Canis lupus familiaris
702888 Macaca mulatta
100158588 Xenopus (Silurana) tropicalis
100172840 Pongo abelii
100339276 Oryctolagus cuniculus
100607439 Nomascus leucogenys
100195855 Salmo salar
79184 Homo sapiens
210766 Mus musculus
316794 Rattus norvegicus
519513 Bos taurus
100516948 Sus scrofa
447688 Xenopus laevis
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