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The study aimed to identify a small set of genetic signatures that may reliably predict the individuals with a high genetic propensity to heroin addiction. A set of 4 genes (JUN (show JUN Proteins), CEBPB (show CEBPB Proteins), PRKCB (show PRKCB Proteins), ENO2 (show ENO2 Proteins), or CEBPG) could predict the diagnosis of heroin addiction with the accuracy rate around 85% in our dataset.
These findings suggest that CEBPG may play an oncogenic role in BCP (show OPN1SW Proteins)-ALL and relies on a mechanism different from CEBPA (show CEBPA Proteins).
HIV-1 Tat (show TAT Proteins)-mediated induction of CCL5 (show CCL5 Proteins) in astrocytes involves NF-kappaB (show NFKB1 Proteins), AP-1 (show FOSB Proteins), C/EBPalpha (show CEBPA Proteins) and C/EBPgamma transcription factors and JAK (show JAK3 Proteins), PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and p38 MAPK (show MAPK14 Proteins) signaling pathways
High CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBP gam (show CEBPB Proteins)ma depletion decreased proliferation and induced senescence in lung tumor cells.
CEBPG mediates the myeloid differentiation arrest induced by CEBPA (show CEBPA Proteins) deficiency in acute myeloid leukemia (show BCL11A Proteins).
C/EBPgamma positively regulates wound repair both in vitro and in vivo, at least in part, by affecting EGFR (show EGFR Proteins) signaling.
Ig/EBP (C/EBPgamma)is constitutively multiubiquitinated & then degraded by the proteasome. Ubiquitination and degradation are suppressed by forming dimers through the leucine zipper domains.
CEBPG is the transcription factor primarily responsible for regulating transcription of key antioxidant and DNA repair genes in non-bronchogenic carcinoma individuals
CEBPG regulates ERCC5 (show ERCC5 Proteins) expression and this regulation is modified by E2F1 (show E2F1 Proteins)/YY1 (show YY1 Proteins) interactions.
Adult Cebpg-/- mice on a mixed strain background show increased early mortality and altered cancer incidence.
HIV-1 Tat (show TAT Proteins)-mediated induction of CCL5 (show CCL5 Proteins) in astrocytes involves NF-kappaB (show NFKB1 Proteins), AP-1 (show JUN Proteins), C/EBPalpha (show CEBPA Proteins) and C/EBPgamma transcription factors and JAK (show JAK3 Proteins), PI3K/Akt (show AKT1 Proteins) and p38 MAPK (show MAPK14 Proteins) signaling pathways
The senescence-suppressing activity of C/EBPgamma required its ability to heterodimerize with C/EBPbeta (show CEBPB Proteins).
CCAAT/enhancer-binding protein gamma is a critical regulator of IL-1beta (show IL1B Proteins)-induced IL-6 (show IL6 Proteins) production in alveolar epithelial cells.
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene.
CCAAT/enhancer-binding protein gamma
, CCAAT/enhancer binding protein (C/EBP), gamma
, leucine zipper transcription factor
, c/EBP gamma
, CCAAT/enhancer binding protein gamma
, G-CSF promoter element 1 binding protein
, GPE1-BP (C/EBP gamma)
, GPE1-binding protein
, granulocyte colony-stimulating factor promoter element 1-binding protein
, immunoglobulin enhancer-binding protein 1
, CCAAT/enhancer binding protein ,gamma
, homolog to a human CCAAT/enhancer binding protein - gamma