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FOXM1 may play a central role in the skp2-cdk1 (show CDK1 Proteins) loop driving tumor progression.
This study is the first to identify the roles of FOXM1 in drug efflux and paclitaxel resistance by regulating the gene transcription of abcc5 (show ABCC5 Proteins), one of the ABC (show ABCB6 Proteins) transporters. Small molecular inhibitors of FOXM1 or ABCC5 (show ABCC5 Proteins) have the potential to overcome paclitaxel chemoresistance in nasopharyngeal carcinoma (NPC (show NPC1 Proteins))patients.
Data suggest that forkhead box M1 (FOXM1) expression is biomarker, and its inhibition is a potential treatment option for synovial sarcoma (SS).
The crucial role of FOXM1 and STMN1 (show STMN1 Proteins) in TKI-induced enrichment of CSC and drug resistance was demonstrated by knockdown of STMN1 (show STMN1 Proteins) and FOXM1 in NSCLC cells.
There was no significant change in FoxM1 mRNA expression with or without FDI (show FDX1 Proteins)-6 treatment.
study demonstrates that USP5 (show USP5 Proteins) plays a critical role in tumorigenesis and progression of pancreatic cancer by stabilizing FoxM1 protein, and provides a rationale for USP5 (show USP5 Proteins) being a potential therapeutic approach against pancreatic ductal adenocarcinoma
O-GlcNAcylation is a central component linking metabolism to invasion and metastasis via an SIRT1 (show SIRT1 Proteins)/ERK (show EPHB2 Proteins)/FOXM1 axis.
Results has uncovered a previous unknown positive feedback loop between AURKA (show AURKA Proteins) and FOXM1 that promotes breast cancer stem cells (BCSCs) phenotypes and drug resistance. It showed that nuclear AURKA (show AURKA Proteins) is recruited by FOXM1 to transactivate the expression of target genes, which also include FOXM1, whereas AURKA (show AURKA Proteins) itself is also a downstream transcriptional target of FOXM1.
The FOXM1 is a negative regulator of CRY2 (show CRY2 Proteins) in breast cancer via enhancing methylation in CRY2 (show CRY2 Proteins) promoter and its high expression is an independent predictor of favorable MR-free survival in ER+ breast cancer patients.
Knockdown of forkhead Box M1 (FoxM1) reduced Prx (show PRDX6 Proteins) II levels in H-ras (show HRAS Proteins)(G12V)-hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells, indicating FoxM1 as a direct transcription factor of Prx (show PRDX6 Proteins) II in HCC (show FAM126A Proteins).
YAP (show YAP1 Proteins) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (show TNNI3 Proteins) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (show INS Proteins)-FoxM1/PLK1/CENP-A (show CENPA Proteins) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (show EGF Proteins) promotes FoxM1 expression through the ERK (show EPHB2 Proteins) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (show PIK3CG Proteins)-selective inhibitor and in Pik3cg (show PIK3CG Proteins)(-/-) mice after LPS (show TLR4 Proteins) challenge. Defective vascular repair in Pik3cg (show PIK3CG Proteins)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (show HOXA10 Proteins) and cyclin D3 (show CCND3 Proteins).
FOXM1 and CENPF (show CENPF Proteins) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (show TP53 Proteins) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
MicroRNA-802 suppresses breast cancer proliferation through down-regulation of FoxM1.
FoxM1 expression correlates with proliferation, invasion and migration in mouse hepatocellular carcinoma cell lines.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
forkhead box protein M1
, forkhead box M1
, forkhead box protein M1-like
, Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, forkhead homolog 16
, winged-helix transcription factor Trident
, INS-1 winged helix