Browse our TNFRSF14 Proteins (TNFRSF14)

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Tumor Necrosis Factor Receptor Superfamily, Member 14 Proteins (TNFRSF14)
On are 33 Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) Proteins from 12 different suppliers available. Additionally we are shipping TNFRSF14 Antibodies (186) and TNFRSF14 Kits (13) and many more products for this protein. A total of 253 TNFRSF14 products are currently listed.
Atar, CD270, HveA, Hvem, LIGHTR, Tnfrs14, TR2
list all proteins Gene Name GeneID UniProt
Rat TNFRSF14 TNFRSF14 366518  
TNFRSF14 8764 Q92956
TNFRSF14 230979  

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TNFRSF14 Proteins (TNFRSF14) by Origin

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Top referenced TNFRSF14 Proteins

  1. Human TNFRSF14 Protein expressed in Insect Cells - ABIN2666456 : Pasero, Speiser, Derré, Olive: The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. in Current opinion in pharmacology 2012 (PubMed)
    Show all 5 references for 2666456

  2. Cynomolgus TNFRSF14 Protein expressed in Human Cells - ABIN2009868 : Montgomery, Warner, Lum, Spear: Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. in Cell 1996 (PubMed)
    Show all 4 references for 2009868

  3. Human TNFRSF14 Protein expressed in Human Cells - ABIN2002595 : Marsters, Ayres, Skubatch, Gray, Rothe, Ashkenazi et al.: Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB ... in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for 2002595

  4. Mouse (Murine) TNFRSF14 Protein expressed in CHO Cells - ABIN2003074 : Schneider, Potter, Ware: Lymphotoxin and LIGHT signaling pathways and target genes. in Immunological reviews 2004 (PubMed)
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  5. Mouse (Murine) TNFRSF14 Protein expressed in Human Cells - ABIN2003072 : Cheung, Humphreys, Potter, Norris, Shumway, Tran, Patterson, Jean-Jacques, Yoon, Spear, Murphy, Lurain, Benedict, Ware: Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 4 references for 2003072

More Proteins for TNFRSF14 Interaction Partners

Human Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) interaction partners

  1. Low HVEM expression is associated with pancreatic and ampullary cancer.

  2. HIV-1 produced from CD4 (show CD4 Proteins)+ T cells bears HSV-2 receptor HVEM and can bind to and enter HSV-2-infected epithelial cells depending on HVEM-gD interaction and the presence of gB/gH/gL.

  3. HVEM is highly expressed in ovarian serous adenocarcinoma tissues and correlated with the patient clinicopathological features.

  4. TNFRSF14 and MAP2K1 (show MAP2K1 Proteins) mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.

  5. genetic landscape of Pediatric-type follicular lymphoma suggests that TNFRSF14 mutations accompanied by copy-number neutral loss of heterozygosity of the 1p36 locus in over 70% of mutated cases, as additional selection mechanism, might play a key role in the pathogenesis of this disease.

  6. The increased immune-stimulatory capacity of lymphoma B cells with TNFRSF14 aberrations had clinical relevance, associating with higher incidence of acute GVHD in patients undergoing allogeneic hematopoietic stem cell transplantation.

  7. These results suggest that TNFRSF14 mutations point towards a diagnosis of follicular lymphomas , and can be used in the sometimes difficult distinction between marginal zone lymphomas and follicular lymphomas

  8. the overexpression of HVEM in ovarian cancer cells may suppress the proliferation and immune function of T cells, thus leading to the development of ovarian cancer. The current study partially explains the immune escape mechanism of ovarian cancer cells.

  9. In eight cases (42%) we observed recurrent copy number loss of chr1:2,352,236-4,574,271, a region containing the candidate tumor suppressor TNFRSF14.

  10. Study report the crystal structure of unbound HVEM, which further contributes to the understanding of the molecular mechanisms controlling recognition between HVEM and its ligands.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) interaction partners

  1. Dendritic cells require BTLA (show BTLA Proteins) and HVEM to actively adjust tolerizing T cell responses under steady-state conditions.

  2. we identified herpes virus entry mediator as a functional receptor that mediates SALM5 (show LRFN5 Proteins)'s suppressive function. Our findings reveal a molecular link between the neuronal system and the immune system, and provide potential therapeutic targets for the control of CNS diseases.

  3. results have revealed a novel role of HVEM on the regulation of IFN-I and immunopathology during Listeria infection.

  4. our studies revealed a novel function of the HVEM cosignaling molecule and its ligands in EAU pathogenesis through the induction of Th1 (show HAND1 Proteins)- and Th17-type T cell responses

  5. Together, these data indicate that HVEM contributes to ocular pathogenesis independently of entry and point to an immunomodulatory role for this protein specifically on radiation-resistant cells.

  6. results demonstrate a role for both nectin-1 (show PVRL1 Proteins) and HVEM as receptors and suggest a further receptor which appears much less efficient.

  7. Authors show that CD4 (show CD4 Proteins)(+) FoxP3 (show FOXP3 Proteins)(+) Tregs up- regulate HVEM (herpes virus entry mediator), which is a binding site for major viral glycoprotein gD, following herpes simplex virus 1 infection.

  8. results support a model whereby BTLA (show BTLA Proteins) on innate leukocytes is triggered by HVEM and delivers negative signals into BTLA (show BTLA Proteins)(+) cells, thereby interfering with the protective immune response to this intestinal parasite.

  9. In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1 (show PVRL1 Proteins), but the restricted presence of HVEM can potentially replace nectin-1 (show PVRL1 Proteins) as a receptor.

  10. One mechanism by which the herpes simplex virus 1 latency-associated transcript enhances latency and reactivation appears to be by upregulating HVEM expression.

TNFRSF14 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.

Alternative names and synonyms associated with TNFRSF14

  • tumor necrosis factor receptor superfamily, member 14 (Tnfrsf14)
  • tumor necrosis factor receptor superfamily, member 14 (TNFRSF14)
  • tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) (Tnfrsf14)
  • Atar protein
  • CD270 protein
  • HveA protein
  • Hvem protein
  • LIGHTR protein
  • Tnfrs14 protein
  • TR2 protein

Protein level used designations for TNFRSF14

tumor necrosis factor receptor superfamily member 14 , tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) , herpesvirus entry mediator A , CD40-like protein , herpes virus entry mediator A , tumor necrosis factor receptor-like 2 , tumor necrosis factor receptor-like gene2 , herpes virus entry mediator

366518 Rattus norvegicus
457221 Pan troglodytes
695042 Macaca mulatta
8764 Homo sapiens
479580 Canis lupus familiaris
230979 Mus musculus
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