HVEM Protein (AA 39-184, AA 102-300) (Fc Tag)
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- Target See all HVEM (TNFRSF14) Proteins
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 39-184, AA 102-300
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Origin
- Human
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Source
- Insect cells (Sf9)
- Purification tag / Conjugate
- This HVEM protein is labelled with Fc Tag.
- Characteristics
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ED50 < 0.1 μg/mL, measured by the neutralization assay using 929 cells in presence of 0.25 ng/mL of human TNF-beta, corresponding to a specific activity of > 1x10^4 units/mg.
AA 39-184, fused with a C-terminal human Fc region AA 102-300 - Purity
- > 95 % by SDS-PAGE and HPLC analyses.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product TNFRSF14 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -20 °C
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- Target
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- Alternative Name
- HVEM (TNFRSF14 Products)
- Synonyms
- ATAR Protein, CD270 Protein, HVEA Protein, HVEM Protein, LIGHTR Protein, TR2 Protein, Atar Protein, HveA Protein, Hvem Protein, Tnfrs14 Protein, TNF receptor superfamily member 14 Protein, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Protein, Tnfrsf14 Protein, TNFRSF14 Protein
- Target Type
- Viral Protein
- Background
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Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 Molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-gamma and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA),which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.Recombinant human HVEM-Fc (rhHVEM-Fc) produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhHVEM-Fc has a molecular mass of around 45 kDa analyzed by reducing SDS-PAGE.
Synonyms: TNFRSF14, TR2 - Molecular Weight
- 45 kDa, observed by reducing SDS-PAGE.
- UniProt
- Q92956, P01857
- Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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