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These results suggest a connection between Ca(2 (show CA2 Antibodies)+)-signaling via excitation-contraction coupling and the regulation of STARS-mediated gene expression in muscles.
STARS signalling pathway is upregulated in response to acute endurance exercise and suggest suggest a novel role co-ordination of PGC-1alpha (show PPARGC1A Antibodies)-induced upregulation of the fat oxidative gene, CPT (show CHPT1 Antibodies)-1beta.
STARS activates serum response factor by inducing the nuclear translocation of myocardin (show MYOCD Antibodies)-related transcription factors .
Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between human and transgenic myocyte enhancer factor-2 and serum response factor.
GATA4-dependent repression of ms1/STARS expression has major implications for MRTF-SRF signaling in the context of cardiac development and disease
a novel striated (show NSDHL Antibodies) muscle activator of Rho signaling and serum response factor-dependent transcription (striated (show NSDHL Antibodies) muscle activator of Rho signaling; STARS)
ABLIM-2 and -3 associate with STARS and directly bind F-actin
Modulates the responsiveness of the heart to stress signaling by functioning as a cytoskeletal intermediary between myocyte enhancer factor-2 and serum response factor.
Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling (By similarity).
actin-binding Rho-activating protein
, striated muscle activator of Rho-dependent signaling