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Our data show that compound heterozygous mutations in KPNA7 (show KPNA6 Proteins) are associated with a human neurodevelopmental disease, and provide the first example of a human disease associated with mutation of a nuclear transport receptor.
Bel1 fragment with residues 215-223, which bears the NLS (show ALDH1A2 Proteins), interacts with KPNA1 (show KPNA1 Proteins), KPNA6 (show KPNA6 Proteins), and KPNA7 (show KPNA6 Proteins).
KPNA7 (show KPNA6 Proteins) silencing inhibits the malignant properties of pancreatic cancer cells in vitro and thereby provide the first evidence on the functional role for KPNA7 (show KPNA6 Proteins) in human cancer.
Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin (show KPNA4 Proteins) beta1 and importin 7 (show IPO7 Proteins).
KPNA7: mRNA specifically expressed in ovary & mature oocyte; protein high in oocyte & early embryo but low in blastocyst; strong binding affinity for nucleoplasmin 2 (show NPM2 Proteins); KPNA7 knockdown in early embryos decreases embryo development; DNA & AA sequences
a decreased H7N9 influenza A virus polymerase activity when importin (show KPNA4 Proteins)-alpha7 was silenced by siRNA, is reported.
a novel importin alpha (show KPNA4 Proteins) family member with distinct subcellular localization and nuclear localization signal binding characteristics
knocking out of Kpna7 induced abnormalities of gene expression (dppa2 (show DPPA2 Proteins), dppa4 (show DPPA4 Proteins), and piwil2) and epigenetic modifications (down-regulation of histone H3K27me3). Biochemical analysis showed that KPNA7 interacts with KPNB1 (show KPNB1 Proteins) (importin (show KPNA4 Proteins)-beta1).
KPNA7 may transport intracellular proteins that possess unique nuclear localisation signals.
Functions in nuclear protein import (By similarity).
karyopherin alpha 7 (importin alpha 8)
, importin subunit alpha-8-like
, importin subunit alpha-8
, karyopherin 7
, karyopherin subunit alpha-7
, importin alpha 8
, importin alpha 2
, nuclear transport receptor
, Karyopherin subunit alpha-7