Alfa-1 Antitrypsin Protein

Catalog No. ABIN1042573

Product Details

Target: Alfa-1 Antitrypsin

Protein Type: Recombinant

Origin: Human

Source: Rice (Oryza sativa)

Characteristics: Activity: 3-5mg OsrAATwill inhibit 1mg PPE with an activity of 10.8 units per mg protein
Formulation: Lyophilized from a 200 myL sterile-filtered solution added Osr HSA for protection.

Purity: > 95 % , SDS Page

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: PBS pH7.0

Storage: -20 °C

References

Zhang, Shi, Jiang, Stupak, Ou, Qiu, An, Li, Yang: "Expression and characterization of recombinant human alpha-antitrypsin in transgenic rice seed." in: Journal of biotechnology, Vol. 164, Issue 2, pp. 300-8, (2013) (PubMed).

Target Details

Target: Alfa-1 Antitrypsin

Synonyms: A1A Protein, A1AT Protein, AAT Protein, PI Protein, PI1 Protein, PRO2275 Protein, alpha1AT Protein, serpin family A member 1 Protein, SERPINA1 Protein

Background: OsrAAT is a Human Recombinant protein produced in Rice, which is a single, non-glycosylated polypeptidechain containing 384 amino acids and has a molecular mass of 43.1 kDa. OsrAAT is a serine protease inhibitor which its targets include elastase, plasmin, collagenase, thrombin, leucocytic proteases, trypsin, chymotrypsin, and plasminogen activator. In its absence, neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children. The OsrAAT protein is purified by chromatographic techniques.