CBR1 Protein (AA 2-277, full length) (GST tag)
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- Target See all CBR1 Proteins
- CBR1 (Carbonyl Reductase 1 (CBR1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 2-277, full length
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CBR1 protein is labelled with GST tag.
- Application
- SDS-PAGE (SDS), ELISA
- Sequence
- SSGIHVALVT GGNKGIGLAI VRDLCRLFSG DVVLTARDVT RGQAAVQQLQ AEGLSPRFHQ LDIDDLQSIR ALRDFLRKEY GGLDVLVNNA GIAFKVADPT PFHIQAEVTM KTNFFGTRDV CTELLPLIKP QGRVVNVSSI MSVRALKSCS PELQQKFRSE TITEEELVGL MNKFVEDTKK GVHQKEGWPS SAYGVTKIGV TVLSRIHARK LSEQRKGDKI LLNACCPGWV RTDMAGPKAT KSPEEGAETP VYLALLPPDA EGPHGQFVSE KRVEQW
- Characteristics
- NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
- Purity
- 90 %
- Top Product
- Discover our top product CBR1 Protein
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Carbonyl Reductase 1 (CBR1) (AA 1-277) protein (GST tag)
CBR1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Carbonyl Reductase 1 (CBR1) (AA 2-277) protein (His tag)Crystallography grade CBR1 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Carbonyl Reductase 1 (CBR1) (AA 2-277) protein (His tag)Crystallography grade CBR1 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Carbonyl Reductase 1 (CBR1) (AA 45-320), (partial) protein (His tag)CBR1 Origin: Human Host: Yeast Recombinant > 90 % SDS
Carbonyl Reductase 1 (CBR1) protein (Myc-DYKDDDDK Tag)CBR1 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Comment
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Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS buffer, 20mM GSH
- Storage
- -20 °C
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- Target
- CBR1 (Carbonyl Reductase 1 (CBR1))
- Alternative Name
- Carbonyl reductase [NADPH] 1 (CBR1 Products)
- Synonyms
- LOC100222525 Protein, MGC131152 Protein, CBR Protein, SDR21C1 Protein, hCBR1 Protein, 9-KPR Protein, AW261796 Protein, CR Protein, Cbr Protein, carbonyl reductase 1 Protein, carbonyl reductase [NADPH] 1 Protein, carbonyl reductase 1 S homeolog Protein, carbonyl reductase Protein, cbr1 Protein, CBR1 Protein, LOC100222525 Protein, cbr1.S Protein, Smp_033530.3 Protein, LOC610164 Protein, Cbr1 Protein
- Background
- Synonyms: 15-hydroxyprostaglandin dehydrogenase [NADP+] NADPH-dependent carbonyl reductase 1 Prostaglandin 9-ketoreductase Prostaglandin-E(2) 9-reductase
- Molecular Weight
- 57.6 kD
- UniProt
- P16152
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