IGF2BP2 Protein (AA 1-220) (His tag,T7 tag)

Catalog No. ABIN1691917

Product Details

Target: IGF2BP2 (Insulin-Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2))

Protein Type: Recombinant

Protein Characteristics: AA 1-220

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This IGF2BP2 protein is labelled with His tag,T7 tag.

Purpose: Recombinant Human IGF2 mRNA-Binding Protein 2/IGF2BP2/IMP2 (C-6His, N-T7 tag)

Sequence: MASMTGGQQM GRGSEFMMNK LYIGNLSPAV TADDLRQLFG DRKLPLAGQV LLKSGYAFVD YPDQNWAIRA IETLSGKVEL HGKIMEVDYS VSKKLRSRKI QIRNIPPHLQ WEVLDGLLAQ YGTVENVEQV NTDTETAVVN VTYATREEAK IAMEKLSGHQ FENYSFKISY IPDEEVSSPS PPQRAQRGDH SSREQGHAPG GTSQARQIDF PLRILVPTQF VGAIIGKEGL TIKNITLEHH HHHH

Characteristics: Recombinant Human Insulin-Like Growth Factor 2 mRNA-Binding Protein 2/IGF2BP2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Thr220) of Human IGF2BP2 fused with a 6His tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: IGF2BP2 (Insulin-Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2))

Alternative Name: IGF2BP2 (IGF2BP2 Products)

Synonyms: IMP-2 Protein, IMP2 Protein, VICKZ2 Protein, p62 Protein, C330012H03Rik Protein, Imp2 Protein, Neilsen Protein, RGD1305614 Protein, insulin like growth factor 2 mRNA binding protein 2 Protein, insulin-like growth factor 2 mRNA binding protein 2 Protein, IGF2BP2 Protein, Igf2bp2 Protein

Sub Type: Fusionprotein

Background: Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition motif) domains. IGF2BP2 binds to the 5'-UTR of the Insulin-Like Growth Factor 2 (IGF2) mRNA. This binding is isoform-specific. IGF2BP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses.
Alternative Names: Insulin-Like Growth Factor 2 mRNA-Binding Protein 2, IGF2 mRNA-Binding Protein 2, IMP-2, Hepatocellular Carcinoma Autoantigen p62, IGF-II mRNA-Binding Protein 2, VICKZ Family Member 2, IGF2BP2, IMP2, VICKZ2

Molecular Weight: 27.2 kDa

UniProt: Q9Y6M1