JAM2 Protein (AA 29-236) (Fc Tag)

Catalog No. ABIN1880658

Product Details

Target: JAM2 (Junctional Adhesion Molecule 2 (JAM2))

Protein Type: Recombinant

Protein Characteristics: AA 29-236

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This JAM2 protein is labelled with Fc Tag.

Purpose: Recombinant Human Junctional Adhesion Molecule B/JAM-B/CD322 (C-Fc)

Sequence: FSAPKDQQVV TAVEYQEAIL ACKTPKKTVS SRLEWKKLGR SVSFVYYQQT LQGDFKNRAE MIDFNIRIKN VTRSDAGKYR CEVSAPSEQG QNLEEDTVTL EVLVAPAVPS CEVPSSALSG TVVELRCQDK EGNPAPEYTW FKDGIRLLEN PRLGSQSTNS SYTMNTKTGT LQFNTVSKLD TGEYSCEARN SVGYRRCPGK RMQVDDLNVD DIEGRMDEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK

Characteristics: Recombinant Human Junctional Adhesion Molecule B/JAM-B produced by transfected human cells is a secreted protein with sequence(Phe29-Asn236) of Human JAM2 fused with a FC tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: JAM2 (Junctional Adhesion Molecule 2 (JAM2))

Alternative Name: Junctional Adhesion Molecule B/JAM-B (JAM2 Products)

Synonyms: JAM2 Protein, cd322 Protein, jam-b Protein, jamb Protein, pro245 Protein, ve-jam Protein, vejam Protein, jam2 Protein, sb:cb1002 Protein, im:7155552 Protein, sc:d0813 Protein, si:ch211-160b11.5 Protein, LOC100227766 Protein, 1110002N23Rik Protein, 2410030G21Rik Protein, 2410167M24Rik Protein, JAM-2 Protein, JAM-B Protein, Jcam2 Protein, VE-JAM Protein, C21orf43 Protein, CD322 Protein, JAMB Protein, PRO245 Protein, VEJAM Protein, junctional adhesion molecule 2 Protein, junctional adhesion molecule 2a Protein, junctional adhesion molecule 2b Protein, junction adhesion molecule 2 Protein, JAM2 Protein, jam2 Protein, jam2a Protein, jam2b Protein, Jam2 Protein

Background: Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 - 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.

Molecular Weight: 50.3 kDa

UniProt: P57087