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ANGPTL3 Protein (His tag)

ANGPTL3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. WB
Catalog No. ABIN2566285
  • Target See all ANGPTL3 Proteins
    ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
    Protein Type
    Recombinant
    Origin
    • 18
    • 7
    • 2
    • 1
    Human
    Source
    • 10
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This ANGPTL3 protein is labelled with His tag.
    Application
    Western Blotting (WB)
    Purity
    >95 % as determined by reduced SDS-PAGE.
    Top Product
    Discover our top product ANGPTL3 Protein
  • Application Notes
    This recombinant protein can be used for WB. For research use only.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -80 °C,-20 °C
    Storage Comment
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
  • Target
    ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
    Alternative Name
    ANGPTL3 (ANGPTL3 Products)
    Synonyms
    fb60e11 Protein, fb66h02 Protein, wu:fb60e11 Protein, wu:fb66h02 Protein, zgc:111943 Protein, ANGPTL3 Protein, LOC100230785 Protein, ANG-5 Protein, ANGPT5 Protein, ANL3 Protein, FHBL2 Protein, hypl Protein, angiopoietin-like 3 Protein, angiopoietin like 3 Protein, angptl3 Protein, ANGPTL3 Protein, Angptl3 Protein
    Background
    Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
    Molecular Weight
    24.6 kDa
    Gene ID
    27329
    NCBI Accession
    NP_055310
    UniProt
    Q9Y5C1
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