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CSF3R Protein (His tag)

CSF3R Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. WB Active
Catalog No. ABIN2566610
  • Target See all CSF3R Proteins
    CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Origin
    • 18
    • 5
    • 2
    Human
    Source
    • 9
    • 7
    • 6
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This CSF3R protein is labelled with His tag.
    Application
    Western Blotting (WB)
    Characteristics

    Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells. The ED50 for this effect is typically 0. 02-2 μg /mL in the presence of 0. 125 ng /mL of recombinant human GCSF.

    Fusion tag: C-His Tag

    Purity
    >95 % as determined by SDS-PAGE.
    Top Product
    Discover our top product CSF3R Protein
  • Application Notes
    This recombinant protein can be used for WB. For research use only.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Storage
    -80 °C,-20 °C
    Storage Comment
    Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
  • Target
    CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))
    Alternative Name
    GCSFR (CSF3R Products)
    Synonyms
    CD114 Protein, GCSFR Protein, Cd114 Protein, Csfgr Protein, G-CSF-R Protein, G-CSFR Protein, CSF3R Protein, gcsfr Protein, cd114 Protein, colony stimulating factor 3 receptor Protein, colony stimulating factor 3 receptor (granulocyte) Protein, colony stimulating factor 3 receptor L homeolog Protein, granulocyte colony-stimulating factor receptor Protein, CSF3R Protein, Csf3r Protein, csf3r Protein, csf3r.L Protein, LOC100433338 Protein
    Background
    Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage. G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region. G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.
    Molecular Weight
    69 kDa
    Gene ID
    1441
    NCBI Accession
    NP_000751
    UniProt
    Q99062
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