Polybromo 1 Protein (PBRM1) (AA 613-734) (His tag,DYKDDDDK Tag)
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- Target See all Polybromo 1 (PBRM1) Proteins
- Polybromo 1 (PBRM1)
- Protein Type
- Recombinant
- Protein Characteristics
- AA 613-734
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This Polybromo 1 protein is labelled with His tag,DYKDDDDK Tag.
- Characteristics
- The peptide corresponding to amino acids 613 - 734 that contains the bromodomain sequences of PBRM1 (accession number NP_060635.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 20.513 kDa. It shows binding specificity for acetylated H3K14.
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- Discover our top product PBRM1 Protein
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Polybromo 1 (PBRM1) (AA 53-345) protein (His tag)
PBRM1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Polybromo 1 (PBRM1) (AA 1-306) protein (GST tag)PBRM1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Polybromo 1 (PBRM1) (AA 1-1634) protein (Strep Tag)Crystallography grade PBRM1 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
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- Restrictions
- For Research Use only
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- Handling Advice
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Storage
- -80 °C
- Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- Target
- Polybromo 1 (PBRM1)
- Alternative Name
- PBRM1 (PBRM1 Products)
- Synonyms
- pb1 Protein, BAF180 Protein, PB1 Protein, 2610016F04Rik Protein, AI507524 Protein, Pb1 Protein, RGD1565549 Protein, polybromo 1 Protein, polybromo 1 L homeolog Protein, protein polybromo-1 Protein, PBRM1 Protein, pbrm1.L Protein, LOC100170602 Protein, pbrm1 Protein, Pbrm1 Protein
- Background
- Polybromo 1 (PBRM1) protein, also known as BRG1-associated factor 180 (BAF180) is the chromatin targeting subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex that is involved in transcriptional activation and repression of select genes. PBRM1 targets chromatin via its six bromodomains that recognize and bind acetylated histone lysine residues. Bromodomains function as 'readers' of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. PBRM1 also acts as an inhibitor of cell proliferation and demonstrates tumor suppressing properties in relation to breast, liver and lung cancers.
- Molecular Weight
- 20.513 kDa
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