-
- Target See all PRMT2 Proteins
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Protein Type
- Recombinant
-
Origin
- Human
-
Source
- Baculovirus
- Purification tag / Conjugate
- This PRMT2 protein is labelled with DYKDDDDK Tag.
- Application
- Enzyme Activity Assay (EAA), Screening Assay (ScA)
- Characteristics
- Recombinant PRMT2 (accession number NP_996845.1) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 47.6 kDa.
- Top Product
- Discover our top product PRMT2 Protein
-
Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-433) protein (GST tag)
PRMT2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-448) protein (Strep Tag)Crystallography grade PRMT2 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Protein Arginine Methyltransferase 2 (PRMT2) (AA 1-433) protein (Strep Tag)Crystallography grade PRMT2 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Protein Arginine Methyltransferase 2 (PRMT2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)PRMT2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Protein Arginine Methyltransferase 2 (PRMT2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)PRMT2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- Application Notes
- Recombinant PRMT2 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. Specific Activity: PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4.May methylate H3R8 and H4.
- Restrictions
- For Research Use only
-
- Handling Advice
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- Storage
- -80 °C
- Storage Comment
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
-
- Target
- PRMT2 (Protein Arginine Methyltransferase 2 (PRMT2))
- Alternative Name
- PRMT2 (PRMT2 Products)
- Synonyms
- PRMT2 Protein, DKFZp459N1919 Protein, HRMT1L1 Protein, Hrmt1l1 Protein, AI504737 Protein, protein arginine methyltransferase 2 Protein, protein arginine methyltransferase 2 L homeolog Protein, protein arginine N-methyltransferase 2 Protein, PRMT2 Protein, Prmt2 Protein, prmt2.L Protein
- Background
- PRMT2 (Protein Arginine Methyltransferase 2) is a member of the protein arginine N-methyltransferase (PRMT) family that is capable of monomethylating and asymmetrically dimethylating arginine residues. PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4. PRMT2, along with NCOA2, acts as a coactivator of androgen receptor (AR)-mediated transactivation. PRMT2 also acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. PRMT2 enhances PGR, PPARY, RARA-mediated transactivation and may inhibit NFκB transcription and promote apoptosis. PRMT2 is known to repress E2F1 transcriptional activity in an Rb-dependent manner and may be involved in growth regulation.
- Molecular Weight
- 47.6 kDa
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding
-
You are here:
