AIRE Protein (Myc-DYKDDDDK Tag)
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- Target See all AIRE Proteins
- AIRE (Autoimmune Regulator (AIRE))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This AIRE protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human AIRE / APECED (transcript variant AIRE-1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product AIRE Protein
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Autoimmune Regulator (AIRE) (AA 1-545) protein (Strep Tag)
Crystallography grade AIRE Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Autoimmune Regulator (AIRE) (AA 1-552) protein (Strep Tag)Crystallography grade AIRE Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Target
- AIRE (Autoimmune Regulator (AIRE))
- Alternative Name
- Aire,apeced (AIRE Products)
- Synonyms
- AIRE1 Protein, APECED Protein, APS1 Protein, APSI Protein, PGA1 Protein, autoimmune regulator Protein, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Protein, AaeL_AAEL013794 Protein, CpipJ_CPIJ001208 Protein, CpipJ_CPIJ001209 Protein, AIRE Protein, Aire Protein
- Background
- This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
- Molecular Weight
- 57.5 kDa
- NCBI Accession
- NP_000374
- Pathways
- Chromatin Binding
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