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BAG4 Protein (Myc-DYKDDDDK Tag)

BAG4 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2715136
  • Target See all BAG4 Proteins
    BAG4 (BCL2-Associated Athanogene 4 (BAG4))
    Protein Type
    Recombinant
    Origin
    • 3
    • 2
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This BAG4 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human BAG4 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product BAG4 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    BAG4 (BCL2-Associated Athanogene 4 (BAG4))
    Alternative Name
    Bag4 (BAG4 Products)
    Synonyms
    BAG-4 Protein, SODD Protein, BAG4 Protein, fd20a04 Protein, wu:fd20a04 Protein, si:dkey-220o5.3 Protein, 2410112I15Rik Protein, ATBAG4 Protein, BCL-2-associated athanogene 4 Protein, BCL2 associated athanogene 4 Protein, BCL2-associated athanogene 4 Protein, BCL-2-associated athanogene 4 Protein, BAG4 Protein, Bag4 Protein, bag4 Protein
    Background
    The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
    Molecular Weight
    49.4 kDa
    NCBI Accession
    NP_004865
    Pathways
    Regulation of Actin Filament Polymerization
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