BAP1 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2715149

Product Details

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This BAP1 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human BAP1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: BAP1 (BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1))

Alternative Name: Bap1 (BAP1 Products)

Synonyms: HUCEP-13 Protein, UCHL2 Protein, BAIAP3 Protein, 2300006C11Rik Protein, AA989761 Protein, AW553466 Protein, mKIAA0272 Protein, uch-x4 Protein, hucep-13 Protein, hucep-6 Protein, uchl2 Protein, si:dkey-42i9.9 Protein, BRCA1 associated protein 1 Protein, Brca1 associated protein 1 Protein, BRCA1 associated protein 1 L homeolog Protein, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) Protein, BAP1 Protein, Bap1 Protein, bap1.L Protein, bap1 Protein

Background: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

Molecular Weight: 80.2 kDa

NCBI Accession: NP_004647