SERPINA1 Protein

Catalog No. ABIN3119637

Product Details

Target: SERPINA1 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))

Protein Type: Native

Origin: Human

Source: Human

Cross-Reactivity (Details): Prepared from plasma shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Purity: >95 %

Application Details

Application Notes: For use in: SDS

Comment:

Extinction Coefficient: 433

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 30 mM Na phosphate, pH 6.5, with 300 mM NaCl

Storage: -20 °C

Storage Comment: -20°C

References

Borel, Tang, Gernoux, Greer, Wang, Barzel, Kay, Shultz, Greiner, Flotte, Brehm, Mueller: "Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of α-1 Antitrypsin Deficiency." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 25, Issue 11, pp. 2477-2489, (2017) (PubMed).

Kadam, Chuan: "Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament." in: International urogynecology journal, Vol. 27, Issue 3, pp. 505, (2016) (PubMed).

Jansen, Falck, de Haan, Hipgrave Ederveen, Razdorov, Lauc, Wuhrer: "LaCyTools: A Targeted Liquid Chromatography-Mass Spectrometry Data Processing Package for Relative Quantitation of Glycopeptides." in: Journal of proteome research, Vol. 15, Issue 7, pp. 2198-210, (2016) (PubMed).

Garratt, Sutanto, Ling, Looi, Iosifidis, Martinovich, Shaw, Buckley, Kicic-Starcevich, Lannigan, Knight, Stick, Kicic: "Alpha-1 Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase." in: American journal of respiratory cell and molecular biology, Vol. 54, Issue 3, pp. 341-9, (2016) (PubMed).

ODwyer, OBrien, Wormald, White, Banville, Hurley, McCarthy, McElvaney, Reeves: "The BLT1 Inhibitory Function of ?-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 8, pp. 3628-41, (2015) (PubMed).

Ramadass, Ghebrehiwet, Kew: "Enhanced recognition of plasma proteins in a non-native state by complement C3b. A possible clearance mechanism for damaged proteins in blood." in: Molecular immunology, Vol. 64, Issue 1, pp. 55-62, (2015) (PubMed).

Ungurs, Sinden, Stockley: "Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 1, pp. L80-7, (2014) (PubMed).

Ramadass, Ghebrehiwet, Smith, Kew: "Generation of multiple fluid-phase C3b:plasma protein complexes during complement activation: possible implications in C3 glomerulopathies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 3, pp. 1220-30, (2014) (PubMed).

Target Details

Target: SERPINA1 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 1 (SERPINA1))

Alternative Name: alpha 1 Antitrypsin (SERPINA1 Products)

Synonyms: AACT Protein, ACT Protein, GIG25 Protein, A1AT Protein, PI Protein, alpha-1-PI Protein, A1A Protein, AAT Protein, PI1 Protein, PRO2275 Protein, alpha1AT Protein, Pi Protein, Spi1 Protein, MGC64429 Protein, serpina1d Protein, Aps Protein, SERPINA3-5 Protein, serpin family A member 3 Protein, alpha-1-antiproteinase F precursor Protein, serpin family A member 1 Protein, alpha-1-antitrypsin Protein, calumenin Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 S homeolog Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 Protein, SH2B adaptor protein 2 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 L homeolog Protein, SERPINA3 Protein, LOC100008973 Protein, SERPINA1 Protein, LOC100328621 Protein, CALU Protein, Serpina1 Protein, serpina1.S Protein, serpina1 Protein, SPIA5 Protein, Sh2b2 Protein, Calu Protein, serpina1.L Protein

Background: Serpina9, Alpha 1 proteinase inhititor, Alpha 1 PI, 3.5S alpha 1 glycoprotein, Inhibitor

Molecular Weight: 52 kDa