PODXL Protein (AA 32-458, partial) (His tag)
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- Target See all PODXL Proteins
- PODXL (Podocalyxin-Like (PODXL))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 32-458, partial
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Origin
- Human
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Source
- Yeast
- Purification tag / Conjugate
- This PODXL protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- QNATQTTTDS SNKTAPTPAS SVTIMATDTA QQSTVPTSKA NEILASVKAT TLGVSSDSPG TTTLAQQVSG PVNTTVARGG GSGNPTTTIE SPKSTKSADT TTVATSTATA KPNTTSSQNG AEDTTNSGGK SSHSVTTDLT STKAEHLTTP HPTSPLSPRQ PTSTHPVATP TSSGHDHLMK ISSSSSTVAI PGYTFTSPGM TTTLLETVFH HVSQAGLELL TSGDLPTLAS QSAGITASSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRF
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product PODXL Protein
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Podocalyxin-Like (PODXL) (AA 22-301) protein (His-IF2DI Tag)
PODXL Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Podocalyxin-Like (PODXL) (AA 23-340) protein (His tag)PODXL Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Podocalyxin-Like (PODXL) (AA 22-404) protein (His tag)Crystallography grade PODXL Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Podocalyxin-Like (PODXL) (AA 23-461) protein (His tag)Crystallography grade PODXL Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Podocalyxin-Like (PODXL) (AA 23-558) protein (rho-1D4 tag)Crystallography grade PODXL Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Podocalyxin-Like (PODXL) (AA 22-503) protein (rho-1D4 tag)Crystallography grade PODXL Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- PODXL (Podocalyxin-Like (PODXL))
- Alternative Name
- PODXL (PODXL Products)
- Synonyms
- Gp200 Protein, PC Protein, PCLP Protein, PCLP-1 Protein, PCB Protein, AW121214 Protein, Ly102 Protein, Pclp1 Protein, podocalyxin Protein, MEP21 Protein, PODXL Protein, Gp135 Protein, PCLP1 Protein, cPCLP1 Protein, podxl Protein, fc18d02 Protein, wu:fc18d02 Protein, Pc Protein, Pcb Protein, Podxl Protein, podocalyxin like Protein, pyruvate carboxylase Protein, podocalyxin-like Protein, PODXL Protein, PC Protein, Podxl Protein, podxl Protein, Pcx Protein
- Background
- Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
- Molecular Weight
- 46.2 kDa
- UniProt
- O00592
- Pathways
- Tube Formation
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