WIF1 Protein (AA 29-379) (His tag)

Catalog No. ABIN622178

This Recombinant WIF1 protein is produced in not_set.

Quick Overview for WIF1 Protein (AA 29-379) (His tag) (ABIN622178)

Target: WIF1 (WNT Inhibitory Factor 1 (WIF1))

Protein Type: Recombinant

Origin: Human

Host: Please inquire

Purity: > 80.0 % as determined by SDS-PAGE.

Product Details

Protein Characteristics: AA 29-379

Purification tag / Conjugate: This WIF1 protein is labelled with His tag.

Sequence: ADLGPPQEES LYLWIDAHQA RVLIGFEEDI LIVSEGKMAP FTHDFRKAQQ RMPAIPVNIH SMNFTWQAAG QAEYFYEFLS LRSLDKGIMA DPTVNVPLLG TVPHKASVVQ VGFPCLGKQD GVAAFEVDVI VMNSEGNTIL KTPQNAIFFK TCQQAECPGG CRNGGFCNER RICECPDGFH GPHCEKALCT PRCMNGGLCV TPGFCICPPG FYGVNCDKAN CSTTCFNGGT CFYPGKCICP PGLEGEQCEI SKCPQPCRNG GKCIGKSKCK CSKGYQGDLC SKPVCEPGCG AHGTCHEPNK CQCQEGWHGR HCNKRYEASL IHALRPAGAQ LRQHTPSLKK AEERRDPPES NYIWSGRLVP RG

Characteristics: Recombinant Human WNT Inhibitory Factor 1

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The WIF1 protein solution contains 1X PBS pH 7.4, 10% glycerol and 1mM PMSF.

Storage: 4 °C

Target Details

Target: WIF1 (WNT Inhibitory Factor 1 (WIF1))

Alternative Name: WNT Inhibitory Factor 1

Background: WIF1 produced in Hi-5 cells is a single, glycosylated polypeptide chain containing 369 AA (29-379 AA) and having a molecular mass of 40.5 kDa, (48 kDa on SDS-PAGE). WIF1 is fused to 16 AA His Tag at C-Terminus and purified by proprietary chromatographic techniques. Introduction: WIF1 binds to wnt proteins and inhibits their activities. WIF1 plays a role in mesoderm segmentation. WNT proteins are extracellular signaling molecules that take part in the control of embryonic development and cancer. WIF1 protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WIF1 takes part in mesoderm segmentation. WIF1 protein is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis. Downregulation of WIF1 takes part in the development and progression of pleomorphic adenomas. WIF1 is a tumor suppressor, specifically in nonfunctioning pituitary tumors. Synonyms: WIF1, WIF-1, Wnt inhibitory factor 1.

Pathways: WNT Signaling, Positive Regulation of fat Cell Differentiation