PCNA Protein (AA 1-261)
Quick Overview for PCNA Protein (AA 1-261) (ABIN667068)
Target
See all PCNA ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-261
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Sequence
- MFEARLVQGS ILKKVLEALK DLINEACWDI SSSGVNLQSM DSSHVSLVQL TLRSEGFDTY RCDRNLAMGV NLTSMSKILK CAGNEDIITL RAEDNADTLA LVFEAPNQEK VSDYEMKLMD LDVEQLGIPE QEYSCVVKMP SGEFARICRD LSHIGDAVVI SCAKDGVKFS ASGELGNGNI KLSQTSNVDK EEEAVTIEMN EPVQLTFALR YLNFFTKATP LSSTVTLSMS ADVPLVVEYK IADMGHLKYY LAPKIEDEEG S
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Characteristics
- PCNA, 1-261 aa, Human, Recombinant, E.coli
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Purification
- > 95% by SDS-PAGE
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Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) protein (His tag)
custom-made PCNA Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) protein (His tag)custom-made PCNA Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) proteinPCNA Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % pure SDS
Proliferating Cell Nuclear Antigen (PCNA) (AA 1-261) protein (GST tag)PCNA Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 20 mM Tris-HCl buffer ( pH 7.5) containing 2 mM EDTA, 20 % glycerol
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Handling Advice
- Avoid repeated freezing and thawing cycles
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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Alternative Name
- PCNA
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Background
- PCNA (Proliferating Cell Nuclear Antigen) is found in the nucleus and is a cofactor of DNA polymerase delta. This protein is associated with DNA synthesis and repair. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. It appears during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA may be induced by uV irradiation, growth factors and eventually by neighbouring tumours. Recombinant human PCNA, was expressed in E. coli and purified by conventional chromatography techniques.
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Molecular Weight
- 28.7 kDa (261aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_002583
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Pathways
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagy
Target
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