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SCO2 Protein (AA 42-266) (His tag)

SCO2 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % by SDS - PAGE SDS
Catalog No. ABIN667861
  • Target See all SCO2 Proteins
    SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))
    Protein Type
    Recombinant
    Protein Characteristics
    AA 42-266
    Origin
    • 4
    • 1
    Human
    Source
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Purification tag / Conjugate
    This SCO2 protein is labelled with His tag.
    Application
    SDS-PAGE (SDS)
    Characteristics
    SCO2, 42-266aa, Human, His tag, E.coli
    Purity
    > 90 % by SDS - PAGE
    Top Product
    Discover our top product SCO2 Protein
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5mg/ml (determined by Bradford assay)
    Buffer
    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 30% glycerol, 2mM DTT, 200mM NaCl
    Storage
    4 °C
  • Target
    SCO2 (SCO2 Cytochrome C Oxidase Assembly Protein (SCO2))
    Alternative Name
    SCO2 (SCO2 Products)
    Synonyms
    CEMCOX1 Protein, MYP6 Protein, SCO1L Protein, SCO cytochrome oxidase deficient homolog 2 (yeast) Protein, SCO2 cytochrome c oxidase assembly protein Protein, SCO2, cytochrome c oxidase assembly protein Protein, SCO2 Protein, Sco2 Protein
    Background
    SCO2 protein belongs to the SCO1/2 family of proteins. Both SCO1 and SCO2 proteins are located on the inner membrane of the mitochondria and plays a crucial role in copper insertion or transport to the active site of cytochrome c oxidase (COX). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Recombinant human SCO2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Protein SCO2 homolog mitochondrial, SCO1L. NCBI no.: NP_005129
    Molecular Weight
    27.4kDa (246aa), confirmed by MALDI-TOF
    Pathways
    Transition Metal Ion Homeostasis, Warburg Effect
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