GNB2L1 Protein (AA 1-317) (His tag)

Catalog No. ABIN668010

Product Details

Target: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Protein Type: Recombinant

Protein Characteristics: AA 1-317

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GNB2L1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Characteristics: GNB2L1, 1-317aa, Human, His tag, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/ml (determined by Bradford assay)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 50% glycerol, 0.2M NaCl, 5mM DTT

Storage: 4 °C

Target Details

Target: GNB2L1 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1))

Alternative Name: GNB2L1 (GNB2L1 Products)

Synonyms: MGC53289 Protein, GNB2L1 Protein, AL033335 Protein, GB-like Protein, Gnb2-rs1 Protein, Rack1 Protein, p205 Protein, RACK1 Protein, H12.3 Protein, HLC-7 Protein, PIG21 Protein, rack1 Protein, wu:fb80d08 Protein, wu:fk65d12 Protein, gnb2-rs1 Protein, h12.3 Protein, hlc-7 Protein, pig21 Protein, C12-3 Protein, c12.3 Protein, guanine nucleotide binding protein, beta 2, related sequence 1 Protein, receptor for activated C kinase 1 Protein, guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 Protein, receptor for activated C kinase 1 L homeolog Protein, Guanine nucleotide-binding protein subunit beta-2-like 1 Protein, gnb2l1 Protein, RACK1 Protein, Rack1 Protein, rack1.L Protein, rack-1 Protein

Background: GNB2L1 was originally identified as an anchoring protein for protein kinase C beta (PKCbeta), which it stabilises in the active state and anchors to membranes or functional sites. However, evidence has accumulated to support a central role of GNB2L1 in critical biological responses. In addition to binding specifically to the active form of PKCbeta isoforms, GNB2L1 also interacts with several other important signaling proteins including the Src kinase family, integrin beta1, integrin beta2, integrin beta3 and integrin beta5, beta-spectrin and dynamin, RasGAP, the androgen receptor, insulin-like growth factor 1 receptor (IGF-1r), Epstein-Barr virus trans-activator protein BZLF1, p73 and pRB. GNB2L1 is ubiquitously expressed in the tissues of higher mammals and humans including brain, liver, and spleen. Recombinant human GNB2L1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Guanine nucleotide-binding protein subunit beta-2-like 1 , Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1. NCBI no.: NP_006089

Molecular Weight: 37.2 kDa (337aa) confirmed by MALDI-TOF

Pathways: cAMP Metabolic Process, Positive Regulation of Endopeptidase Activity