Cardiotrophin 1 Protein (CTF1)
Quick Overview for Cardiotrophin 1 Protein (CTF1) (ABIN935293)
Target
See all Cardiotrophin 1 (CTF1) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Sequence
- MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS A
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Characteristics
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Purified recombinant Human Cardiotrophin 1 protein
Expression System: E.coli
Bioactivity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ? 1.0 ng/mL, corresponding to a specific activity of ? 1 x 10^6 units/mg. -
Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
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Cardiotrophin 1 (CTF1) (AA 1-201) protein (His tag)
custom-made CTF1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cardiotrophin 1 (CTF1) (AA 1-203) protein (His tag)custom-made CTF1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cardiotrophin 1 (CTF1) (AA 1-201) protein (GST tag)CTF1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cardiotrophin 1 (CTF1) (Active) proteinCTF1 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Cardiotrophin 1 (CTF1) (AA 1-203) protein (His-IF2DI Tag)CTF1 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Cardiotrophin 1 (CTF1) (AA 1-203) protein (His-IF2DI Tag)CTF1 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Supplied as a lyophilized powder.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Cardiotrophin 1 (CTF1)
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Alternative Name
- Cardiotrophin 1
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Background
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CT-1 is a member of the IL6 family of cytokines which also includes LIF, CNTF, OSM (Oncostatin M), IL11, IL6 and possibly NT-1/ BSF-3. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the adult heart, skeletal muscle, ovary, colon, prostate and fetal lung and signals through the LIF receptor and the gp130 receptor subunit. CT-1 has the ability to induce cardiac myocyte hypertrophy, and enhances the survival of cardiomyocyte and different neuronal populations. Biologically active human CT-1 is synthesized as a 201 amino acid polypeptide lacking a hydrophobic N-terminal secretion signal sequence.
Alternative Names: Cardiotrophin 1, CT-1 protein, Cardiotrophin-1 protein, Cardiotrophin-1 protein, Cardiotrophin-1, Cardiotrophin 1 protein, Cardiotrophin 1 -
Molecular Weight
- 21.5 kDa
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Pathways
- JAK-STAT Signaling
Target
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