CD96 antibody

Catalog No. ABIN2192060

Product Details anti-CD96 Antibody

Target: CD96

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD96 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Sterility: 0.2 μm filtered

Clone: NK92-39

Application Details

Application Notes: For flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies in vitro dilutions have to be made according to the amounts of CD96 to be inactivated.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-CD96 antibody (ABIN2192060)

Fuchs, Cella, Giurisato, Shaw, Colonna: "Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 3994-8, (2004) (PubMed).

Target Details for CD96

Target: CD96

Alternative Name: CD96 (CD96 Products)

Synonyms: 1700109I12Rik antibody, Tactile antibody, TACTILE antibody, CD96 antigen antibody, CD96 molecule antibody, Cd96 antibody, CD96 antibody

Background: The monoclonal antibody NK92.39 reacts with CD96, also known as T cell-Activated Increased Late Expression (Tactile). CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR/CD155). Furthermore, CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells. This mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. The monoclonal antibody NK92.39 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.