HIST1H2BJ,HIST1H2BK,HIST3H2BB (AA 98-126), (C-Term) antibody

Catalog No. ABIN1881414

Product Details

Target: HIST1H2BJ,HIST1H2BK,HIST3H2BB

Binding Specificity: AA 98-126, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: X, B, Pr, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HIST1H2BJ/HIST1H2BK/HIST3H2BB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the C-terminal region of human HIST1H2BJ/HIST1H2BK/HIST3H2BB.

Clone: RB40819

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References

Shi, Levinson, Duan, Sanders, Zheng, Peer, Dudbridge, Holmans, Whittemore, Mowry, Olincy, Amin, Cloninger, Silverman, Buccola, Byerley, Black, Crowe, Oksenberg, Mirel, Kendler, Freedman, Gejman: "Common variants on chromosome 6p22.1 are associated with schizophrenia." in: Nature, Vol. 460, Issue 7256, pp. 753-7, (2009) (PubMed).

Benyamin, McRae, Zhu, Gordon, Henders, Palotie, Peltonen, Martin, Montgomery, Whitfield, Visscher: "Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels." in: American journal of human genetics, Vol. 84, Issue 1, pp. 60-5, (2009) (PubMed).

Beck, Nielsen, Matthiesen, Jensen, Sehested, Finn, Grauslund, Hansen, Jensen: "Quantitative proteomic analysis of post-translational modifications of human histones." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 7, pp. 1314-25, (2006) (PubMed).

Pavri, Zhu, Li, Trojer, Mandal, Shilatifard, Reinberg: "Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II." in: Cell, Vol. 125, Issue 4, pp. 703-17, (2006) (PubMed).

Target Details

Target: HIST1H2BJ,HIST1H2BK,HIST3H2BB

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq].

Molecular Weight: 13904

NCBI Accession: NP_066402

UniProt: P06899