SNAIL antibody (N-Term)

Catalog No. ABIN388809

Product Details anti-SNAIL Antibody

Target: SNAIL (SNAI1)

Binding Specificity: AA 9-39, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNAIL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SNAI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human SNAI1.

Clone: RB01400

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-SNAIL antibody (ABIN388809)

Chiu, Wen, Wang, Hsu, Tsai, Hung, Tseng, Shyr: "Role of estrogen receptors and Src signaling in mechanisms of bone metastasis by estrogen receptor positive breast cancers." in: Journal of translational medicine, Vol. 15, Issue 1, pp. 97, (2018) (PubMed).

Gil, Ciołczyk-Wierzbicka, Dulińska-Litewka, Laidler: "Integrin-linked kinase regulates cadherin switch in bladder cancer." in: Tumour biology, Vol. 37, Issue 11, pp. 15185-15191, (2017) (PubMed).

Ishikawa, Sreekumar, Spee, Nazari, Zhu, Kannan, Hinton: "αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition." in: The American journal of pathology, Vol. 186, Issue 4, pp. 859-73, (2016) (PubMed).

Nakamura, Nishikawa, Saito, Sakai, Sasaki, Hashimoto, Okamoto, Suehiro, Yamasaki, Sakaida: "Decitabine inhibits tumor cell proliferation and up-regulates e-cadherin expression in Epstein-Barr virus-associated gastric cancer." in: Journal of medical virology, (2016) (PubMed).

Wei, Zhang, Wang, Li, Wang, Sun, Shen, Yang, Zhou, Du: "FOXM1 promotes lung adenocarcinoma invasion and metastasis by upregulating SNAIL." in: International journal of biological sciences, Vol. 11, Issue 2, pp. 186-98, (2015) (PubMed).

Lee, Jeon, Ju, Jeong, Kim, Yoo, Park, Han, Kang: "Dlx-2 is implicated in TGF-?- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation." in: International journal of oncology, Vol. 46, Issue 4, pp. 1768-80, (2015) (PubMed).

Fukui, Ogawa, Shimmura, Hatou, Ichihashi, Yaguchi, Hirayama, Kawakita, Tsubota: "Possible involvement of epithelial-mesenchymal transition in fibrosis associated with IgG4-related Mikulicz's disease." in: Modern rheumatology / the Japan Rheumatism Association, pp. 1-7, (2015) (PubMed).

Borges, Perez, Thompson, Radisky, Geiger, Storz: "Effective Targeting of Estrogen Receptor-Negative Breast Cancers with the Protein Kinase D Inhibitor CRT0066101." in: Molecular cancer therapeutics, Vol. 14, Issue 6, pp. 1306-16, (2015) (PubMed).

Liang, Wang, Zhu, Yang, An, Li, Niu, Chen, Tian: "BMP-7 attenuated silica-induced pulmonary fibrosis through modulation of the balance between TGF-?/Smad and BMP-7/Smad signaling pathway." in: Chemico-biological interactions, (2015) (PubMed).

Li, Jia, Ren, Liu, Gong, Wang, Zhang, Zhao: "Axl mediates tumor invasion and chemosensitivity through PI3K/Akt signaling pathway and is transcriptionally regulated by slug in breast carcinoma." in: IUBMB life, Vol. 66, Issue 7, pp. 507-18, (2014) (PubMed).

Chen, Miyazaki, Nishizawa, Kurahashi, Leach, Wang: "MTA3 regulates CGB5 and Snail genes in trophoblast." in: Biochemical and biophysical research communications, Vol. 433, Issue 4, pp. 379-84, (2013) (PubMed).

Sehrawat, Kim, Vogt, Singh: "Suppression of FOXQ1 in benzyl isothiocyanate-mediated inhibition of epithelial-mesenchymal transition in human breast cancer cells." in: Carcinogenesis, Vol. 34, Issue 4, pp. 864-73, (2013) (PubMed).

Muenst, Däster, Obermann, Droeser, Weber, von Holzen, Gao, Viehl, Oertli, Soysal: "Nuclear expression of snail is an independent negative prognostic factor in human breast cancer." in: Disease markers, Vol. 35, Issue 5, pp. 337-44, (2013) (PubMed).

Giner, Machado, Noguera, Villamon, Pellin, Calabuig-Fariñas, Peydro-Olaya, Navarro, Llombart-Bosch: "The epithelial mesenchymal transition process in wilms tumor: a study based on a xenograft model." in: Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry, Vol. 19, Issue 4, pp. 369-75, (2011) (PubMed).

Cheng, Auersperg, Leung: "Inhibition of p53 induces invasion of serous borderline ovarian tumor cells by accentuating PI3K/Akt-mediated suppression of E-cadherin." in: Oncogene, Vol. 30, Issue 9, pp. 1020-31, (2011) (PubMed).

Pham, Chen, Li, King, Angst, Dawson, Park, Reber, Hines, Eibl: "Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors." in: Pancreas, Vol. 39, Issue 3, pp. 332-9, (2010) (PubMed).

Matsuura, Chiang, Lai, He, Wang, Ramkumar, Uchida, Ryo, Lu, Liu: "Pin1 promotes transforming growth factor-beta-induced migration and invasion." in: The Journal of biological chemistry, Vol. 285, Issue 3, pp. 1754-64, (2010) (PubMed).

Arimoto-Ishida, Sakata, Sawada, Nakayama, Nishimoto, Mabuchi, Takeda, Yamamoto, Isobe, Okamoto, Lengyel, Suehara, Morishige, Kimura: "Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation." in: Endocrinology, Vol. 150, Issue 9, pp. 4306-15, (2009) (PubMed).

Ogawa, Shimmura, Kawakita, Yoshida, Kawakami, Tsubota: "Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease." in: The American journal of pathology, Vol. 175, Issue 6, pp. 2372-81, (2009) (PubMed).

Kim, Choi, Choi, Cheong, Kim, Kwon, Kim, Choi: "Anti-invasive activity of histone deacetylase inhibitors via the induction of Egr-1 and the modulation of tight junction-related proteins in human hepatocarcinoma cells." in: BMB reports, Vol. 42, Issue 10, pp. 655-60, (2009) (PubMed).

Target Details for SNAIL

Target: SNAIL (SNAI1)

Alternative Name: SNAI1 (SNAI1 Products)

Synonyms: SLUGH2 antibody, SNA antibody, SNAH antibody, SNAIL antibody, SNAIL1 antibody, dJ710H13.1 antibody, AI194338 antibody, Sna antibody, Sna1 antibody, Snail antibody, Snail1 antibody, SNAI1 antibody, BG:DS01845.1 antibody, CG3956 antibody, Dmel\\CG3956 antibody, Sco antibody, br28 antibody, br29 antibody, l(2)35Db antibody, l(2)br28 antibody, l(2)br29 antibody, l(3)br28 antibody, l35Db antibody, sn antibody, Xsnail antibody, sna antibody, snail1 antibody, xSna antibody, Snai antibody, sna2 antibody, snail2 antibody, cb643 antibody, sna-1 antibody, sna1 antibody, snai1 antibody, snail1a antibody, zgc:109820 antibody, snail family transcriptional repressor 1 antibody, snail family zinc finger 1 antibody, snail homolog 1 (Drosophila) antibody, snail antibody, zinc-finger transcription factor Snail antibody, snail family zinc finger 1 S homeolog antibody, protein escargot antibody, transcription factor protein antibody, snail zinc finger protein antibody, snail family zinc finger 1b antibody, snail family zinc finger 1a antibody, SNAI1 antibody, Snai1 antibody, sna antibody, snail antibody, snai1.S antibody, LOC410464 antibody, snai1b antibody, snai1a antibody

Background: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo.

Molecular Weight: 29083

NCBI Accession: NP_005976

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling