Progerin (AA 604-611) antibody

Catalog No. ABIN1042661

Product Details

Target: Progerin

Binding Specificity: AA 604-611

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Application: Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunoprecipitation (IP), ELISA

Sequence: GAQSPQNC

Specificity: Specifically recognizes Progerin (LaminAdelta50) and does not cross-react with endogenous prelamin A

Purification: Protein G

Immunogen: Synthetic peptide conjugated to KLH derived from within residues 604 - 611 (GAQSPQNC) at the C terminus of Human Progerin

Clone: 13A4D4

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try,WB: 1/500. Detects a band of approximately 70 kDa

Comment:

Myeloma, fusion partners: X63-Ag8.653

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

References

Liu, Barkho, Ruiz, Diep, Qu, Yang, Panopoulos, Suzuki, Kurian, Walsh, Thompson, Boue, Fung, Sancho-Martinez, Zhang, Yates, Izpisua Belmonte: "Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome." in: Nature, Vol. 472, Issue 7342, pp. 221-5, (2011) (PubMed).

Target Details

Target: Progerin

Alternative Name: Progerin 

Gene ID: 24380

OMIM: 150330