LRP6 antibody (pThr1479)

Catalog No. ABIN540939

Product Details anti-LRP6 Antibody

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Binding Specificity: pThr1479

Reactivity: Human, Mouse, Rat, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRP6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Dot Blot (DB)

Purpose: Rabbit polyclonal antibody raised against synthetic phosphopeptide of LRP6.

Sequence: KGTYF

Specificity: This antibody recognizes ~180 KDa of human LRP6.

Cross-Reactivity: Cow, Human, Mouse, Rat

Characteristics: Antibody Reactive Against Synthetic Peptide.

Immunogen: Synthetic phosphopeptide corresponding to residues surrounding T1479 of human LRP6.

Application Details

Application Notes: Western Blot (0.1-1 μg/mL)
ELISA (0.01-0.1 μg/mL)
Immunoprecipitation (2-5 μg/mL)
The optimal working dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In TBS, pH 7.2 (BSA, 10 % Proclin300)

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Store at 4°C. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.

References for anti-LRP6 antibody (ABIN540939)

Wang, Chi, Yuan, Zhou, Yin, Zhang, Peng: "Astragaloside IV inhibits the up-regulation of Wnt/?-catenin signaling in rats with unilateral ureteral obstruction." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 5, pp. 1316-28, (2014) (PubMed).

Del Valle-Pérez, Arqués, Vinyoles, de Herreros, Duñach: "Coordinated action of CK1 isoforms in canonical Wnt signaling." in: Molecular and cellular biology, Vol. 31, Issue 14, pp. 2877-88, (2011) (PubMed).

Casagolda, Del Valle-Pérez, Valls, Lugilde, Vinyoles, Casado-Vela, Solanas, Batlle, Reynolds, Casal, de Herreros, Duñach: "A p120-catenin-CK1epsilon complex regulates Wnt signaling." in: Journal of cell science, Vol. 123, Issue Pt 15, pp. 2621-31, (2010) (PubMed).

Khan, Vijayakumar, de la Torre, Rotolo, Bafico: "Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7291-301, (2007) (PubMed).

Target Details for LRP6

Target: LRP6 (Low Density Lipoprotein Receptor-Related Protein 6 (LRP6))

Alternative Name: LRP6 (LRP6 Products)

Synonyms: lrp6-A antibody, Xlrp6 antibody, adcad2 antibody, lrp6 antibody, LRP6 antibody, ADCAD2 antibody, C030016K15Rik antibody, Cd antibody, Gw antibody, LDL receptor related protein 6 antibody, LDL receptor related protein 6 L homeolog antibody, LDL receptor related protein 6 S homeolog antibody, low density lipoprotein receptor-related protein 6 antibody, low-density lipoprotein receptor-related protein 6 antibody, LRP6 antibody, lrp6.L antibody, lrp6.S antibody, lrp6 antibody, Lrp6 antibody, LOC590395 antibody

Gene ID: 4040

Pathways: WNT Signaling, Tube Formation