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Human NEPH1 Protein expressed in Human Cells - ABIN2006642
MALMO, SHAGASS, DAVIS: A method for the investigation of somatic response mechanisms in psychoneurosis. in Science (New York, N.Y.) 1951
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Mouse (Murine) NEPH1 Protein expressed in Human Cells - ABIN2007493
Sellin, Huber, Gerke, Quack, Pavenstädt, Walz: NEPH1 defines a novel family of podocin interacting proteins. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
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maintaining high levels of Neph1 at the membrane using a podocyte cell line overexpressing chimeric Neph1 increased the ability of podocytes to resist PAN-induced injury and PAN-induced albumin (show ALB Proteins) leakage
Neph1-CD adopts a global shape in solution, and its interaction with ZO-1 (show TJP1 Proteins) involves multiple sites.
Localization of Neph1 to the podocyte cell membrane is altered in the presence of mutant Myo1c (show MYO1C Proteins), and is actin dependent. Knockdown of Myo1c (show MYO1C Proteins) inhibits Neph1 membrane localization. Neph1 is critical for the maintenance of glomerular function.
A striking finding in this study is the lack of contribution of NEPH1, NPHS1, and NPHS2 genes in 15 Asian families with steroid-resistant nephrotic syndrome.
common variants in LRRC7, KIRREL, NPHS2 and ACTN4 (show ACTN4 Proteins) do not appeear to contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes
Neph1 but not nephrin (show NPHS1 Proteins) specifically binds to adaptor protein Grb2 (show GRB2 Proteins) and tyrosine kinase (show TXK Proteins) Csk (show CSK Proteins) in a phosphorylation-dependent manner.
Neph1-Nephrin (show NPHS1 Proteins) proteins bind the Par3 (show F2RL2 Proteins)-Par6 (show PARD6A Proteins)-atypical protein kinase C (show PRKCZ Proteins) (aPKC) complex to regulate podocyte cell polarity
tyrosine phosphorylation of Neph1 mediated by Fyn (show FYN Proteins) results in significantly increased Neph1 and ZO-1 (show TJP1 Proteins) binding, suggesting a critical role for Neph1 tyrosine phosphorylation in reorganizing the Neph1-ZO-1 (show TJP1 Proteins) complex.
Here we demonstrate that Neph1, Neph2, and Neph3 are expressed differentially in various tissues during ontogenesis in mouse and chicken.
Fyn (show FYN Proteins) catalyzes Nephrin (show NPHS1 Proteins) phosphorylation in podocyte detergent-resistant membrane fractions.
nephrin (show NPHS1 Proteins) and Neph1 interact and have roles in glomerular permeability
In the adult brain, Neph1 is seen in the olfactory nerve layer and the glomerular layer of the olfactory bulb, in the hippocampus, and in cerebellar Purkinje cells. At the ultrastructural level, Neph1 is seen in dendritic shafts of pyramidal neurons.
Nephrin-Neph1 complex transduces phosphorylation-mediated signals that assemble an actin polymerization complex at the podocyte intercellular junction.
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2\; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003
, kin of IRRE-like protein 1
, kin of irregular chiasm-like protein 1
, nephrin-like protein 1
, kin of IRRE like 1
, nephrin 1