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Catalytic inactivation of MGRN1 results in elevated levels of GP78 (show AMFR Proteins) and a consequential increase in the initiation of mitophagy.
Mahogunin-mediated alpha-tubulin (show TUBA4A Proteins) ubiquitination via noncanonical K6 linkage regulates microtubule stability and mitotic spindle orientation.
data suggest that MGRN1 selectively targets misfolded proteins for degradation and may exhibit viable therapeutic potential for the treatment of spongiform neurodegeneration
It therefore seems probable that the role of MGRN1 in the adrenal relates to the trafficking and/or degradation of the melanocortin 2 receptor.
a role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 (show TSG101 Proteins) is a specific Mahogunin substrate
Study shows that both (Ctm)PrP and cyPrP can interact with and disrupt the function of Mahogunin (Mgrn), a cytosolic ubiquitin ligase whose loss causes spongiform neurodegeneration.
Findings suggest that mahogunin ring finger-1 contributes to the clearance of toxic mutant copper-zinc superoxide dismutase (show SOD1 Proteins) inclusions likely through autophagic pathway.
ATRN (show ATRN Proteins) also has no effect on prion (show PRNP Proteins) disease onset or progression and discuss possible mechanisms that could cause vacuolation of the central nervous system in Mgrn1 and Atrn (show ATRN Proteins) null mutant mice
pigment-type switching likely requires MGRN1's ubiquitin ligase activity but not its ability to bind TSG101 or NEDD4.
Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase (show MUL1 Proteins) do not influence prion (show PRNP Proteins) disease.
the md and mg mutations rescue the A(y) phenotypes by a primarily cAMP-independent mechanism promoting trafficking of MC4R and likely MC1R away from the lysosome toward the cell surface.
positional cloning of mahoganoid, encoding a novel 494-amino acid protein containing a C3HC4 RING (really interesting new gene) domain that may function as an E3 ubiquitin ligase (show MUL1 Proteins)
a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion (show PRNP Proteins) diseases but without accumulation of protease-resistant prion protein (show PRNP Proteins)
Mahoganoid mutation (Mgrn1md) on insulin (show INS Proteins) sensitivity suggests that Mgrn1md may be increasing insulin (show INS Proteins) sensitivity via the hypothalamic melanocortin-3 receptor (show MC3R Proteins) pathway.
Mgrn1 mutant embryos show abnormal expression of asymmetrically expressed genes involved in LR patterning.
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.
mahogunin, ring finger 1
, probable E3 ubiquitin-protein ligase MGRN1
, E3 ubiquitin-protein ligase MGRN1
, RING finger protein 156
, mahogunin RING finger protein 1
, mahogunin ring finger protein 1