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Human Polyclonal SH2D1A Primary Antibody for WB - ABIN306863
Tangye, Lazetic, Woollatt, Sutherland, Lanier, Phillips: Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. in Journal of immunology (Baltimore, Md. : 1950) 1999
Show all 4 references for ABIN306863
High LAT1 (show LAT Antibodies) expression correlated with significantly shorter prostate specific antigen (show KLK3 Antibodies) recurrence-free survival in patients receiving androgen deprivation therapy
We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (show SLAMF1 Antibodies))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (show ZMYM2 Antibodies)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
Study of SAP (show APCS Antibodies) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (show CD244 Antibodies) functional assay allows identification of all cases
Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (show APCS Antibodies) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (show SLAMF1 Antibodies) peptide.
Signaling lymphocytic activation molecule (SLAM)/SLAM (show SLAMF1 Antibodies)-associated protein pathway regulates human B-cell tolerance.
In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS Antibodies) is nonfunctional, not only abolishing the activating function of 2B4 (show CD244 Antibodies), but rendering this receptor inhibitory.
our data reveal how SAP (show APCS Antibodies) nucleates a previously unknown signaling complex involving NTB-A (show SLAMF6 Antibodies) and LCK (show LCK Antibodies) to potentiate restimulation-induced cell death of activated human T cells.
SAP (show APCS Antibodies) is a new actor downstream of PECAM-1 (show PECAM1 Antibodies) and its binding regulates PECAM-1 (show PECAM1 Antibodies) mediated cell adhesion.
SAP (show APCS Antibodies) is an essential molecule for autoimmune antibody production.
SLAM (show SLAMF1 Antibodies)-SAP (show APCS Antibodies) signaling promotes differentiation of IL-17 (show IL17A Antibodies)-producing T cells and progression of experimental autoimmune encephalomyelitis.
these data suggest that SAP (show APCS Antibodies) is critical for regulating type II NKT (show CTSL1 Antibodies) cell responses.
functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability
Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (show APCS Antibodies)-/- mice and in Rag-/- mice into which B cells derived from SAP (show APCS Antibodies)-/- mice together with wt CD4 (show CD4 Antibodies)+ T cells had been transferred.
SAP (show APCS Antibodies) plays an essential role in CIA (show NCOA5 Antibodies) because of Fyn (show FYN Antibodies)-independent and Fyn (show FYN Antibodies)-dependent effects on TFH cells and, possibly, other T cell types.
SAP (show APCS Antibodies) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.
Loss of SAP (show APCS Antibodies) expression is associated with invariant NKT (show CTSL1 Antibodies) cell cytotoxicity and defective lytic synapse formation.
SAP (show APCS Antibodies) is required for the development of innate phenotype in H2-M3--restricted Cd8 (show CD8A Antibodies)(+) T cells.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
serum amyloid P-component
, Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, SH2 domain protein 1A
, Duncan disease homolog