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Results show that miR-1 (show FSD1 Proteins) is downregulated in osteosarcoma cells but both of its targets Med1 (show MED1 Proteins) and Med31 were overexpressed suggesting that MiR-1 (show FSD1 Proteins) plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 (show MED1 Proteins) and Med31.
Elmo1 (show ELMO1 Proteins) increased the cytoplasmic localization of Med31.
As the Mediator complex is a transcriptional co-activator, results suggest that Med31 functions to promote the transcription of genes required for embryonic growth and cell proliferation.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
mediator complex subunit 31
, mediator complex subunit soh1
, mediator of RNA polymerase II transcription subunit 31
, mediator of RNA polymerase II transcription, subunit 31 homolog
, hypothetical protein
, mediator complex subunit SOH1