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SIRT1 (show SIRT1 Proteins) gene knock-out may aggravate cartilage degeneration in osteoarthritis by activating the SREBP2 protein-mediated PI3K/AKT (show AKT1 Proteins) signalling pathway, suggesting that SIRT1 (show SIRT1 Proteins) gene may play a protective role against osteoarthritis.
SREBP-2 is critical for survival and limb patterning during development
Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR (show NGFR Proteins) that via p38 MAPK (show MAPK14 Proteins) and caspase-3 (show CASP3 Proteins) mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF (show NGFB Proteins) and pro-NGF (show NGFB Proteins).
This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Proteins).
activation of the sterol regulatory element binding protein-2 (SREBP2) was found to be downstream of ER stress, and this activation was affirmed to account for the intracellular accumulation of cholesterol using RNAi technique
ITCH modulates SIRT6 (show SIRT6 Proteins) and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE (show APOE Proteins) null mice
SREBP2-induced miR (show MLXIP Proteins)-92a targets key molecules in endothelial homeostasis, including sirtuin 1 (show SIRT1 Proteins), Kruppel-like factor 2, and Kruppel-like factor 4 (show KLF4 Proteins), leading to NOD-like receptor family pyrin domain-containing 3 inflammasome activation and endothelial nitric oxide synthase (show NOS3 Proteins) inhibition.
The cholesterol-lowering effects of FGF21 (show FGF21 Proteins) are abrogated by hepatic expression of sterol regulatory element-binding protein-2.
Data indicate that Leishmania exploits macrophage cholesterol-dependent sterol regulatory element binding factor 2 (SREBP2) circuit to facilitate its entry and survival within the host.
Demonstrate that the activation of FXR (show NR1H4 Proteins) uncouples the expression of nuclear SREBP-2 and miR (show MLXIP Proteins)-33, and the regulation of their respective target genes.
Dietary flavones counteract phorbol 12-myristate 13-acetate-induced SREBP-2 processing in hepatic cells.
Data show that mutant p53 protein (show TP53 Proteins) activates the sterol regulatory element-binding proteins SREBP-1 (show SREBF1 Proteins) and SREBP-2-mediated signaling pathways in prostate cancer (PCa (show FLVCR1 Proteins)) cells.
The connections of EGFR (show EGFR Proteins) and ERBB4 (show ERBB4 Proteins) signaling with SREBP-2-regulated cholesterol metabolism are likely to be important in ERBB (show EGFR Proteins)-regulated developmental processes and may contribute to metabolic remodeling in ERBB (show EGFR Proteins)-driven cancers.
Akt1 (show AKT1 Proteins) and Akt2 (show AKT2 Proteins) activated both SREBP-1 (show SREBF1 Proteins) and SREBP-2, whereas Akt3 (show AKT3 Proteins) upregulated SREBP-1 (show SREBF1 Proteins) to enhance hepatitis C virus translation.
knockdown of endogenous SREBP2 in HepG2 cells lowered ACSL1 (show Acsl1 Proteins) mRNA and protein levels.
Data suggest that Hepacivirus (HCV) activates hepatocyte NLRP3 (show NLRP3 Proteins) inflammasomes, induces lipogenic enzymes/lipid droplet formation, and up-regulates transport of SREBF1 (show SREBF1 Proteins)/SREBF2/SCAP (show SH2D2A Proteins) from ER to Golgi where SREBPs undergo proteolytic activation by S1P (show MBTPS1 Proteins)/S2P (show MBTPS2 Proteins).
Data suggest lysophosphatidylcholine (LPC (show PCSK7 Proteins)) up-regulates SREBP-2 and cholesterol efflux in vascular endothelium; 25-hydroxycholesterol (25-HC) inhibits these effects of LPC (show PCSK7 Proteins); both LPC (show PCSK7 Proteins) and 25-HC up-regulate release of interleukin-6 (show IL6 Proteins) and interleukin-8 (show IL8 Proteins).
the results of the present study showed that luteolin modulates HMGCR (show HMGCR Proteins) transcription by decreasing the expression and nuclear translocation of SREBP-2.
performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
dysregulation of SIRT1 (show SIRT1 Proteins)-AMPK (show PRKAA1 Proteins)-SREBP and stimulation of NLRP3 (show NLRP3 Proteins) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
KLF13 (show KLF13 Proteins) and SREBP-Sp1 (show SP1 Proteins) activation interact to regulate low density lipoprotein receptor (show LDLR Proteins) promoter function
This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.
sterol regulatory element binding transcription factor 2
, sterol regulatory element-binding protein 2-like
, sterol regulatory element binding protein 2
, sterol regulatory element-binding protein 2
, sterol regulatory element-binding transcription factor 2
, class D basic helix-loop-helix protein 2
, sterol regulatory element binding factor 2