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The renal cell cancers associated polymorphic HIF-binding site at chromosome 12p12.1 regulates BHLHE41 expression.
Findings suggest that basic helix-loop-helix family, member e41 protein (DEC2) suppresses cell cycle progression of the mesenchymal cells.
DEC1 (show BHLHE40 ELISA Kits), at least partly, exerted a pro-apoptotic effect, whereas DEC2 exerted an anti-apoptotic effect in paclitaxel-induced apoptosis of human prostate cancer cells.
the present study indicated that SHARP1 acts as a tumor suppressor in thyroid cancer and that its downregulation may contribute to the proliferation, migration and invasion of thyroid cancer cells through mechanisms possibly involving HIF1alpha (show HIF1A ELISA Kits)
Study found that DEC2 was a direct target of miR (show MLXIP ELISA Kits)-138.
DEC2 is aberrantly expressed in rheumatoid arthritis tissue, it is induced by TNFalpha (show TNF ELISA Kits) and not only affects the expression of genes belonging to molecular clock but also significantly impacts on the expression of IL-1beta (show IL1B ELISA Kits) as well as other inflammatory genes.
BHLHE40 (show BHLHE40 ELISA Kits)/41 are promising markers to predict the aggressiveness of each Endometrial Neoplasm case and that molecular targeting strategies involving BHLHE40 (show BHLHE40 ELISA Kits)/41 and SP1 (show PSG1 ELISA Kits) may effectively regulate Endometrial Neoplasm progression.
DEC2 facilitates HIF-1alpha (show HIF1A ELISA Kits) stabilization and promotes HIF-1 (show HIF1A ELISA Kits) activation in osteosarcoma.
DEC2 participates in hypoxia-induced cell proliferation by functioning as a target gene of the PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway and regulating the expression of c-Myc (show MYC ELISA Kits).
SHARP1 interacted with HIF-1alpha (show HIF1A ELISA Kits) physically.
Bhlhe41 directly repressed the expression of cell-cycle regulators and inhibitors of BCR (show BCR ELISA Kits) signaling while enabling pro-survival cytokine signaling. Thus, Bhlhe41 controls the development, BCR (show BCR ELISA Kits) repertoire and self-renewal of B-1a cells.
Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.
abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 and SHARP2 (show BHLHE40 ELISA Kits).
SENP1 (show SENP1 ELISA Kits) enhances adipogenesis through de-SUMOylation of Sharp-1, which then releases Sharp-1 repression of PPARgamma (show PPARG ELISA Kits) expression and adipocyte differentiation. These results reveal SENP1 (show SENP1 ELISA Kits) as a novel regulator in adipogenesis.
DEC2 regulates cellular function by modulating the expression of Twist1 (show TWIST1 ELISA Kits)
These results demonstrate that Sharp-1 regulates muscle regenerative capacity, at least in part, by modulation of TGF-beta (show TGFB1 ELISA Kits) signaling
Data show that G9a (show EHMT2 ELISA Kits), a lysine methyltransferase, is involved in Sharp-1-mediated inhibition of muscle differentiation.
Interactions of Per1 (show PER1 ELISA Kits)/2 and Dec2 in the regulation of period, phase, and rhythm sustainment are cell-type specific.
RORalpha suppresses adipogenic differentiation at a later stage of differentiation by RORE-mediated stimulation of Dec1 (show BHLHE40 ELISA Kits) and Dec2 expression.
Results suggest a partially redundant and bidirectional regulatory function for Dec1/2 genes in transcriptional translational feedback loops and conservation of Per1-Dec synergism between vertebrate and invertebrate clocks.
This gene encodes a transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic helix-loop-helix factors. The encoded protein functions as a transcriptional repressor and as a regulator of molecular clock. Defects in this gene are associated with the short sleep phenotype.
basic helix-loop-helix domain containing, class B, 3
, basic helix-loop-helix family, member e41
, class E basic helix-loop-helix protein 41
, differentially expressed in chondrocytes protein 2
, enhancer-of-split and hairy-related protein 1
, bHLH transcriptional factor Dec2
, basic helix-loop-helix domain containing, class B3
, class B basic helix-loop-helix protein 3