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Mrf4 (myf6) is dynamically expressed in differentiated zebrafish skeletal muscle
mrf4 but not myog (show MYOG Proteins) can fully rescue myogenesis in the myod (show MYOD1 Proteins)/myf5 (show MYF5 Proteins) double morphant via a selective and robust activation of myod (show MYOD1 Proteins). Rescue does not happen spontaneously, because the gene is expressed only at the onset of muscle differentiation
findings identified miR (show MLXIP Proteins)-374b directly targets Myf6 and negatively regulates myogenesis
Mrf4 has a role in priming embryonic founder cells to become adult muscle stem cells
Intrinsic muscle factor MRF4 plays an important role in maintenance of neuromuscular junctions.
Data demonstrated that Myf6 is Tceal7 (show TCEAL7 Proteins) upstream transactivators using transcriptional assays.
MRF4 targets the proximal region of M-cadherin promoter and bind the E4-box.
Hox (show MSH2 Proteins) genes produce global patterns in the axial skeleton; Myf5 (show MYF5 Proteins) and Myf6 have roles in rib formation
Mrf4 expression precedes or is contemporaneous with that of Myf5 (show MYF5 Proteins), suggesting that this transcription factor plays a hitherto unsuspected role in myogenesis
an enhancer element directs MRF4 gene expression primarily in fast muscle fibers
elements within a 7.5-kb promoter fragment of the MRF4 gene are sufficient to drive the embryonic wave of expression very similar to the endogenous gene in somites of mouse embryos
skeletal muscle is present in the new Myf5 (show MYF5 Proteins):Myod (show MYOD1 Proteins) double-null mice only when Mrf4 expression is not compromised
A conserved myf6 promoter drives transgenic expression in Xenopus embryonic somites and adult muscle.
XMRF4 protein does not require innervation during muscle regeneration
XMRF4 protein accumulated in somite nuclei slightly after XMRF4 transcripts
The myogenic basic helix-loop-helix family of transcription factors, MyoD (show MYOD1 Proteins), Myf5 (show MYF5 Proteins), myogenin (show MYOG Proteins), and MRF4, can each activate the muscle differentiation program.
Myogenin (show MYOG Proteins) and myogenic differentiation factor D (MyoD (show MYOD1 Proteins)) mRNAs increased (P < 0.05) in young and old, whereas myogenic factor (show MYOG Proteins) (myf)-5 (show MYF5 Proteins) mRNA increased in young only (P < 0.05). Myf-6 protein increased (P < 0.05) in both young and old.
Pietrain pigs exhibited significant higher expression of MYF6 and hypermethylated E2F1 (show E2F1 Proteins) binding element within MYF6 5'-regulatory region as compared with Duroc pigs.
The expression level of Myf6 gene does not indicate significant differences between muscles, ages and breeds.
The porcine MYF6 gene was amplified and sequenced and compared with MYF6 gene sequences of other species. The amino acid sequence was deduced and an interspecies homology analysis was performed.
Associations between the genotype at the MYF6 locus and carcass quality traits appeared to be breed-dependent.
MRF4 and H-FABP (show FABP3 Proteins) genes are associated with growth traits in Qinchuan cattle and related hybrids [MRF4]
The protein encoded by this gene is a probable basic helix-loop-helix (bHLH) DNA binding protein involved in muscle differentiation. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM).
myogenic factor 6
, myogenic factor 6 (herculin)
, muscle-specific regulatory factor 4
, Myogenic factor 6 (herculin)
, myogenic factor 6 b
, class C basic helix-loop-helix protein 4
, myogenic factor 6, transcription activator
, myogenic factor 6 a
, skeletal muscle-specific DNA-binding protein