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The in vitro assays demonstrate the binding of the C-terminus of AtGCN2 to uncharged tRNA molecules and the enzymatic activities of AtGCN2 on both eIF2alpha homologues in A. thaliana.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Stress-resistant translation of c-Src (show SRC Proteins) mRNA is mediated by eIF2A (show EIF2S1 Proteins).
GHRH (show GHRH Proteins) and GHRH-R (show GHRHR Proteins) loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt (show AKT1 Proteins) and eIF2a (show EIF2S1 Proteins) pathways.
These findings suggest that phosphorylated-eIF2alpha regulates synaptic actions of nicotine in both mice and humans, and that reduced phosphorylated-eIF2alpha may enhance susceptibility to nicotine (and other drugs of abuse) during adolescence.
The results suggest that dephosphorylation of eIF2a (show EIF2S1 Proteins) by GADD34 (show PPP1R15A Proteins) plays an important role in doxorubicin resistance of MCF-7/ADR (show AKR1B1 Proteins) cells.
The Newcastle disease virus-induced translation shutoff at late infection times was attributed to sustaining phosphorylation of eIF2a (show EIF2S1 PLURAL_@35658@), which is mediated by continual activation of PKR (show PKLR PLURAL_@35658@) and degradation of PP1 (show PPA1 PLURAL_@35658@).
We identified EIF2A (show EIF2S1 Proteins) phosphorylation as a novel early molecular event occurring in response to NAMPT (show NAMPT Proteins) inhibition and mediating protein synthesis arrest.
These experiments connect embryonic stem cell growth factors to eIF2alpha phosphorylation.
analysis of the ER stress response in immunogenic cell death and the potential value of eIF2alpha phosphorylation as a biomarker for this clinically relevant variant of apoptosis [review]
The data highlight independent interactions of PP1 (show PPA1 Proteins) and eIF2alpha with GADD34 (show PPP1R15A Proteins), demonstrating that GADD34 (show PPP1R15A Proteins) functions as a scaffold both in vitro and in cells
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA (show PPP1CA Proteins) via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (show ATF4 Proteins) expression. (eIF2a = eukaryotic initiation factor-2alpha (show EIF2S1 Proteins); PPP1CA (show PPP1CA Proteins) = protein phosphatase 1 catalytic subunit alpha; Atf4 (show ATF4 Proteins) = activating transcription factor 4 (show ATF4 Proteins))
ER stress-induced increase in ATF4 (show ATF4 Proteins) and CHOP (show DDIT3 Proteins) expression is initiated by an increase in Atf4 (show ATF4 Proteins) and Chop (show DDIT3 Proteins) mRNA, which is also dependent upon eIF2alpha phosphorylation.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Thus, during addiction, cocaine hijacks translational control by p-eIF2alpha, initiating synaptic potentiation and addiction-related behaviors.
in mouse skeletal muscle stem cells, general repression of translation, mediated by the phosphorylation of translation initiation factor (show TIF1 Proteins) eIF2alpha at serine 51 (P-eIF2alpha), is required to maintain the quiescent state
Skeletal muscle-specific (show EIF3K Proteins) eukaryotic translation initiation factor 2alpha (show EIF2S1 Proteins) phosphorylation controls amino acid metabolism and fibroblast growth factor 21 (show FGF21 Proteins)-mediated non-cell-autonomous energy metabolism.
PGRN (show GRN Proteins) is a key regulator of insulin (show INS Proteins) resistance and PGRN (show GRN Proteins) may mediate its effects, at least in part, by inducing ER stress via the PERK (show EIF2AK3 Proteins)-eIF2alpha dependent pathway
Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002
65 kDa eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2 subunit 1
, eukaryotic translation initiation factor 2 subunit alpha
, Eukaryotic translation initiation factor 2A
, eukaryotic translation initiation factor 2A, 65kDa
, eukaryotic translation initiation factor
, eukaryotic translation initiation factor 2A-like
, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
, eukaryotic initiation factor 2alpha
, eukaryotic translation initiation factor 2
, eukaryotic translation initiation factor 2alpha
, minute (1) 14C