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Human Monoclonal ACTR3 Primary Antibody for IF, IHC (p) - ABIN564363
Morel, Parton, Gruenberg: Annexin A2-dependent polymerization of actin mediates endosome biogenesis. in Developmental cell 2009
Show all 2 Pubmed References
Arp2 (show ACTR2 Antibodies)/3 complex regulates mitochondrial-dependent Ca(2 (show CA2 Antibodies)+) signaling in response to salt stress.
The work indicates that regulation of actin reassembly through ARP2 (show ACTR2 Antibodies)/3 complex activity is crucial for stomatal regulation.
The rapid growth of roots in the light requires a functional ARP2 (show ACTR2 Antibodies)/3-SCAR complex.
BRK1 (show BRK1 Antibodies) is required for accumulation of SCAR1 (show WASF1 Antibodies) protein in vivo, potentially explaining the apparently essential role of BRK1 (show BRK1 Antibodies) in ARP2 (show ACTR2 Antibodies)/3 complex function
Differences among SCARs in mRNA levels and the biochemical efficiency of ARP2 (show ACTR2 Antibodies)/3 activation may explain the functional contributions of individual genes
We find that the expression of the actin polymerization complex Arp2/3 is reduced in dysbindin-deficient cells, thus affecting actin-dependent phenotypes
Arp2 (show AICDA Antibodies) and Arp3 (show ANGPTL6 Antibodies) expression was increased under atherosclerotic conditions both in ApoE (show APOE Antibodies)-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
possess a mechanism to pass through micrometric constrictions. This mechanism is based on a rapid Arp2/3-dependent actin nucleation around the nucleus that disrupts the nuclear lamina, the main structure limiting nuclear deformability.
demonstrate that the Arp2 (show AICDA Antibodies)/3 complex in higher eukaryotes is actually a family of complexes with different properties
Platelet actin nodule formation is dependent on WASp and the ARP2 (show AICDA Antibodies)/3 complex.
Arp2/3 complex is an essential regulator of adipocyte development through control of the formation of cortical actin structures, which may facilitate nutrient uptake and signalling events.
WASH complex regulates Arp2 (show AICDA Antibodies)/3 complex and is required for cytokinesis and polar body extrusion.
Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
The Arp2 (show AICDA Antibodies)/3 complex may regulate mouse embryo development via its effect on cell division.
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
evidence of a direct protein-protein interaction between PKD2 (show PKD2 Antibodies) and Arp2 (show ACTR2 Antibodies)/3
miR (show MLXIP Antibodies)-24-1*/let-7a*-ARP2 (show ACTR2 Antibodies)/3 complex-RAC (show AKT1 Antibodies) isoforms pathway may represent a novel pathogenic mechanism for Hirschsprung disease.
Authors found that ARP3 and profilin1 (show PFN1 Antibodies) were 2 binding partners of LMO2 (show LMO2 Antibodies), primarily in cytoplasm. LMO2 (show LMO2 Antibodies). LMO2 (show LMO2 Antibodies) mediated the assembly of a complex including ARP3, profilin1 (show PFN1 Antibodies), and actin monomer, increased actin monomer binding to profilin1 (show PFN1 Antibodies), and promoted lamellipodia/filopodia formation in basal-type breast cancer cells.
Arp2 (show ACTR2 Antibodies) and Arp3 expression was increased under atherosclerotic conditions both in ApoE (show APOE Antibodies)-/- mice and in oxidized low-density lipoproteins stimulated human coronary artery endothelial cells (HCAECs).
These findings indicate that inhibition of the Rac1WAVE2Arp2/3 signaling pathway may promote radiosensitivity, which may partially result from the downregulation of CFL1 (show VPS72 Antibodies) in U251 human glioma cells.
Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.
demonstrate that the Arp2 (show ACTR2 Antibodies)/3 complex in higher eukaryotes is actually a family of complexes with different properties
Platelet actin nodule formation is dependent on WASp and the ARP2 (show ACTR2 Antibodies)/3 complex.
Suggest alpha5beta1/Arp2/Arp3/FHOD3 pathway reprograms the actin cytoskeleton to promote invasive migration and local invasion in vivo.
The loss of the Arp2 (show ACTR2 Antibodies)/3 complex acts as a stress that initiates cell cycle arrest by triggering p16INK4a/p14Arf (show CDKN2A Antibodies) transcription.
crystal structure of Arp2 (show ACTR2 Antibodies)/3 complex
These results demonstrate an important role for CRMP-1 (show CRMP1 Antibodies) in Listeria actin comet tail formation and open the possibility that CRMP-1 (show CRMP1 Antibodies) controls cell motility by modulating Arp2 (show ACTR2 Antibodies)/3 activation.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
interacts with contactin and N-WASp
Data show that L. monocytogenes motility can be separated into an Arp2 (show ACTR2 Antibodies)/3-dependent nucleation phase, and an Arp2 (show ACTR2 Antibodies)/3-independent elongation phase which is dependent upon fascin (show FSCN1 Antibodies).
crystal structures of Arp2/3 complex with bound ATP or ADP
WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament.
domain rearrangements of Arp2 and Arp3 result in a closed conformational state consistent with an "actin-dimer" model for the active state
The specific function of this gene has not yet been determined\; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene.
, actin-like protein 3
, Actin-like protein 3
, ARP3 actin-related protein 3 homolog
, actin-related protein 3
, ARP3 actin-related protein 3 homolog (yeast)
, actin-related protein 3 homolog (yest)
, ARP3 (actin-related protein 3, yeast) homolog