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These data demonstrate that FGF-6 may be considered a regulator of bone metabolism as shown by its activity on both osteoblasts and osteoclasts.
FGF6 exhibits antitumor activity in vitro and correlates with expression of FGF receptors in medulloblastoma cells
A crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress.
We show that the combined loss of FGF2 (show FGF2 Proteins) and FGF6 leads to severe dystrophic changes in the musculature.
In the absence of FGF6, the mechanisms leading to myofibre hypertrophy were mediated specifically by an IGF-II/IGF2R (show IGF2R Proteins) signalling pathway distinct from the classic mechanism involving IGF-I (show IGF1 Proteins) and IGF1R (show IGF1R Proteins).
a role for FGF6 in the maintenance of a reserve pool of progenitor cells in the skeletal muscle
At high doses, FGF6 stimulates the proliferation of the myogenic stem cells, whereas at lower doses it regulates both muscle differentiation and muscle phenotype via a calcineurin-signaling pathway.
Involvement of FGF6 in myogenesis. Review.
Rescue experiments supported the idea of a specific relationship between FGF6 and Spry 2 (show SPRY2 Proteins), both being known for their particular involvement in myogenesis.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation.
fibroblast growth factor 6
, heparin secretory-transforming protein 2
, heparin-binding growth factor 6
, fibroblast growth factor 4