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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||32 Antibodies||236 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||10 Antibodies|
|Flow Cytometry (FACS)||3 Antibodies||27 Antibodies|
|Immunocytochemistry (ICC)||2 Antibodies||17 Antibodies|
|Immunofluorescence (IF)||9 Antibodies||24 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||45 Antibodies|
|Immunohistochemistry (IHC)||34 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||25 Antibodies|
|Immunoprecipitation (IP)||5 Antibodies|
|Western Blotting (WB)||95 Antibodies|
|Dot Blot (DB)||19 Antibodies|
|Antigen||Fibroblast Growth Factor Receptor 1 (FGFR1) Antibodies|
|Epitope||AA 19-48, N-Term Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This FGFR1 antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|10 references available|
|Supplier||Log in to see|
Product Details anti-FGFR1 AntibodyTarget Details FGFR1 Application Details Handling References for anti-FGFR1 Antibody (ABIN1882081) Images
|Purification||This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This FGFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19~48 amino acids from the N-terminal region of human FGFR1.|
Target Details FGFR1Product Details anti-FGFR1 Antibody Application Details Handling References for anti-FGFR1 Antibody (ABIN1882081) Images back to top
|Alternative Name||FGFR1 (FGFR1 Antibody Abstract)|
FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of the gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.
Synonyms: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR, Fibroblast growth factor receptor 1, Basic fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, N-sam, Proto-oncogene c-Fgr, CD_antigen=CD331, Flags: Precursor
|NCBI Accession||NP_075593, NP_001167537, NP_075594, NP_001167536, NP_001167535, NP_001167534, NP_001167538, NP_056934, NP_075598|
|Research Area||Cancer, Growth Factors, Tyrosine Kinases, Angiogenesis, Cytokines, Receptors|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-FGFR1 Antibody Target Details FGFR1 Handling References for anti-FGFR1 Antibody (ABIN1882081) Images back to top
|Application Notes||FACS: 1:10-50,WB: 1:1000,IHC (p): 1:50-100,IF: 1:50-100|
|Restrictions||For Research Use only|
HandlingProduct Details anti-FGFR1 Antibody Target Details FGFR1 Application Details References for anti-FGFR1 Antibody (ABIN1882081) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-FGFR1 Antibody (ABIN1882081)Product Details anti-FGFR1 Antibody Target Details FGFR1 Application Details Handling Images back to top
|Product cited in:||
Mohanan, Temburni, Kappes et al.: "L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor." in: Clinical & experimental metastasis, Vol. 30, Issue 4, pp. 507-20, 2013 (PubMed).
Page, Ambady, Holmes et al.: "Induction of stem cell gene expression in adult human fibroblasts without transgenes." in: Cloning and stem cells, Vol. 11, Issue 3, pp. 417-26, 2009 (PubMed).
Mondrinos, Koutzaki, Lelkes et al.: "A tissue-engineered model of fetal distal lung tissue." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 293, Issue 3, pp. L639-50, 2007 (PubMed).
Sahni, Francis: "Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3." in: Blood, Vol. 104, Issue 12, pp. 3635-41, 2004 (PubMed).
Lundin, Rönnstrand, Cross et al.: "Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin." in: Experimental cell research, Vol. 287, Issue 1, pp. 190-8, 2003 (PubMed).
Fu, Abu-Khalil, Morrison et al.: "Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain." in: The Journal of comparative neurology, Vol. 462, Issue 2, pp. 265-73, 2003 (PubMed).
Kiselyov, Skladchikova, Hinsby et al.: "Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP." in: Structure (London, England : 1993), Vol. 11, Issue 6, pp. 691-701, 2003 (PubMed).
Baumann, Kunapuli, Tracy et al.: "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors." in: The Journal of biological chemistry, Vol. 278, Issue 18, pp. 16198-208, 2003 (PubMed).
Jiao, Greendorfer, Zhang et al.: "Alternatively spliced FGFR-1 isoform signaling differentially modulates endothelial cell responses to peroxynitrite." in: Archives of biochemistry and biophysics, Vol. 410, Issue 2, pp. 187-200, 2003 (PubMed).
Hauge: "[Expeditions to high altitudes--what can we learn from them?]." in: Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Vol. 111, Issue 8, pp. 926-8, 1991 (PubMed).
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