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Browse our HER2 Proteins (ERBB2)

Full name:
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Proteins (ERBB2)
On www.antibodies-online.com are 83 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Proteins from 18 different suppliers available. Additionally we are shipping HER2 Antibodies (1527) and HER2 Kits (41) and many more products for this protein. A total of 1733 HER2 products are currently listed.
Synonyms:
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
list all proteins Gene Name GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

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HER2 Proteins (ERBB2) by Origin

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Top referenced HER2 Proteins

  1. Human HER2 Protein expressed in Human Cells - ABIN2001858 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986 (PubMed)
    Show all 6 references for ABIN2001858

  2. Dog (Canine) HER2 Protein expressed in Human Cells - ABIN2008862 : Lai, Lemke: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. in Neuron 1991 (PubMed)
    Show all 5 references for ABIN2008862

  3. Rat (Rattus) HER2 Protein expressed in Human Cells - ABIN2009129 : Gullick, Bottomley, Lofts, Doak, Mulvey, Newman, Crumpton, Sternberg, Campbell: Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein. in The EMBO journal 1992 (PubMed)
    Show all 5 references for ABIN2009129

  4. Mouse (Murine) HER2 Protein expressed in Human Cells - ABIN2008223 : Codony-Servat, Albanell, Lopez-Talavera, Arribas, Baselga: Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. in Cancer research 1999 (PubMed)
    Show all 5 references for ABIN2008223

  5. Rhesus Monkey HER2 Protein expressed in Human Cells - ABIN2009727 : Tzahar, Yarden: The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. in Biochimica et biophysica acta 1998 (PubMed)
    Show all 5 references for ABIN2009727

  6. Human HER2 Protein expressed in HEK-293 Cells - ABIN2181216 : Piechocki, Wu, Jones, Jacob, Gibson, Ethier, Abrams, Yagita, Venuprasad, Wei: Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 4 references for ABIN2181216

  7. Mouse (Murine) HER2 Protein expressed in HEK-293 Cells - ABIN2181042 : Carraway, Rossi, Komatsu, Price-Schiavi, Huang, Guy, Carvajal, Fregien, Carraway, Carraway: An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for ABIN2181042

More Proteins for HER2 Interaction Partners

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. A role for Her2/neu in identifying high-risk patients for malignant transformation.

  2. A trend of decreasing Her2/neu expression with increasing grade of tumor was observed.

  3. In breast cancer patients treated with trastuzumab, the germline Ala1170Pro homozygous ERBB2 genotype was associated with a lower likelihood of the occurrence of a cardiac event compared with Pro/Pro + Ala/Pro genotypes.

  4. HER2 mutations are rare in HER2-positive Japanese breast cancer patients.

  5. Breast cancer patients with HER2 equivocal status have no significantly higher risk of recurrence.

  6. Overexpression of HER-2 with high level of PSA (show PLAG1 Proteins) are associated with prostatic adenocarcinoma.

  7. HER2 gene amplification is associated with breast cancer.

  8. miR (show MLXIP Proteins)-34a, like ErbB2, might be a diagnostic target in breast cancer.

  9. This concise handbook provides oncologists and other healthcare providers with crucial updates in the field, including an updated review of the current understanding of the biology of the HER2 pathway, an overview of HER2-testing, and evidence-based discussions of available and emerging HER2-targeted treatment options

  10. HER2-positive tumors in our study had a lower Ki-67 (show MKI67 Proteins) index and were p53 (show TP53 Proteins)-positive.

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis

  2. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)

  3. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity

  4. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (show HIF1A Proteins)-VEGF (show VEGFA Proteins) signaling axis in mediating HER2-induced tumor angiogenesis.

  5. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

  6. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 and ErbB3 (show ERBB3 Proteins).

  7. ErbB2 receptor tyrosine kinase (show ERBB3 Proteins) in AECs was activated by annexin V (show ANXA5 Proteins), and blockade reduced the fibrotic potential of annexin V (show ANXA5 Proteins)-treated AEC-conditioned medium.

  8. Disabling of the erbB (show EGFR Proteins) pathway followed by IFNg (show IFNG Proteins) modifies phenotype and enhances genotoxic eradication of breast tumors.

  9. Ptk6 (show PTK6 Proteins) promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

  10. PTPN12 (show PTPN12 Proteins)-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.

HER2 (ERBB2) Protein Profile

Protein Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)
  • c-erbB2 protein
  • c-neu protein
  • CD340 protein
  • Erbb-2 protein
  • HER-2 protein
  • HER-2/neu protein
  • HER2 protein
  • mKIAA3023 protein
  • MLN 19 protein
  • Neu protein
  • NGL protein
  • TKR1 protein

Protein level used designations for ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

GENE ID SPECIES
426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
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