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Browse our HER2 Proteins (ERBB2)

Full name:
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Proteins (ERBB2)
On www.antibodies-online.com are 82 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Proteins from 17 different suppliers available. Additionally we are shipping HER2 Antibodies (1518) and HER2 Kits (42) and many more products for this protein. A total of 1724 HER2 products are currently listed.
Synonyms:
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
list all proteins Gene Name GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

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HER2 Proteins (ERBB2) by Origin

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Top referenced HER2 Proteins

  1. Human HER2 Protein expressed in Human Cells - ABIN2001858 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986 (PubMed)
    Show all 6 references for ABIN2001858

  2. Dog (Canine) HER2 Protein expressed in Human Cells - ABIN2008862 : Lai, Lemke: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. in Neuron 1991 (PubMed)
    Show all 5 references for ABIN2008862

  3. Mouse (Murine) HER2 Protein expressed in Human Cells - ABIN2008225 : Gullick, Bottomley, Lofts, Doak, Mulvey, Newman, Crumpton, Sternberg, Campbell: Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein. in The EMBO journal 1992 (PubMed)
    Show all 5 references for ABIN2008225

  4. Mouse (Murine) HER2 Protein expressed in Human Cells - ABIN2008223 : Codony-Servat, Albanell, Lopez-Talavera, Arribas, Baselga: Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. in Cancer research 1999 (PubMed)
    Show all 5 references for ABIN2008223

  5. Cynomolgus HER2 Protein expressed in Human Cells - ABIN2010109 : Tzahar, Yarden: The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. in Biochimica et biophysica acta 1998 (PubMed)
    Show all 5 references for ABIN2010109

  6. Human HER2 Protein expressed in HEK-293 Cells - ABIN2181216 : Piechocki, Wu, Jones, Jacob, Gibson, Ethier, Abrams, Yagita, Venuprasad, Wei: Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 4 references for ABIN2181216

  7. Mouse (Murine) HER2 Protein expressed in HEK-293 Cells - ABIN2181042 : Carraway, Rossi, Komatsu, Price-Schiavi, Huang, Guy, Carvajal, Fregien, Carraway, Carraway: An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for ABIN2181042

More Proteins for HER2 Interaction Partners

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. Targeting this interaction of membrane surface glycoprotein and its animal lectin in Her-2 negative breast cancer may be of therapeutic value

  2. Her2 mutation is associated with response to therapy in lung cancer.

  3. HER2 was overexpressed in colorectal cancer cell lines. Its expression level was negatively regulated by miR331-3p. HER2 knockdown inhibited cell proliferation and phosphorylation of Akt and ERK1/2.

  4. PKCalpha (show PKCa Proteins) Attenuates Jagged-1 (show JAG1 Proteins)-Mediated Notch (show NOTCH1 Proteins) Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance

  5. Has moderate activity in HER2-overexpressing tumors.

  6. Quantitative HER2 measurement by SRM (show SRM Proteins)-MS is superior to IHC and ISH (show ANTXR2 Proteins) in predicting outcome after treatment with anti-HER2 therapy

  7. HER2 amplification is not associated with pancreatic ductal adenocarcinoma.

  8. The ratios of IGF-I (show IGF1 Proteins)/IGFBP-3 (show IGFBP3 Proteins) were increased in postmenopausal Taiwanese women with breast cancer, irrespective of their ages, ER and PR statuses, and HER2 expression.

  9. NRF2 (show GABPA Proteins) regulates both HER2 and HER3 (show ERBB3 Proteins) receptors to influence cellular responses to HER2 targeting.

  10. Study demonstrated that NAMPT (show NAMPT Proteins), VEGF (show VEGFA Proteins) and HER2 were overexpressed in breast tumors as well as in the serum and their circulating levels declined after tumor removal, suggesting a clinical application of this triplet as biomarker for breast cancer diagnosis.

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

  2. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 and ErbB3 (show ERBB3 Proteins).

  3. ErbB2 receptor tyrosine kinase (show ERBB3 Proteins) in AECs was activated by annexin V (show ANXA5 Proteins), and blockade reduced the fibrotic potential of annexin V (show ANXA5 Proteins)-treated AEC-conditioned medium.

  4. Disabling of the erbB (show EGFR Proteins) pathway followed by IFNg (show IFNG Proteins) modifies phenotype and enhances genotoxic eradication of breast tumors.

  5. Ptk6 (show PTK6 Proteins) promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

  6. PTPN12 (show PTPN12 Proteins)-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.

  7. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity.

  8. These results indicate that OCAM (show NCAM2 Proteins) exerts a posttranscriptional control on the ErbB2 signalling in spinal cord stem cells. This study adds further support for considering cell adhesion molecules as regulators of the ErbB (show EGFR Proteins) signalling

  9. the Krt6a (show KRT6A Proteins)-positive subset of mammary epithelial cells can be induced to form cancer by ErbB2.

  10. These results suggested that DS/Cu treatment may be a promising therapy for the prevention of erbB2-positive breast cancer

HER2 (ERBB2) Protein Profile

Protein Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)
  • c-erbB2 protein
  • c-neu protein
  • CD340 protein
  • Erbb-2 protein
  • HER-2 protein
  • HER-2/neu protein
  • HER2 protein
  • mKIAA3023 protein
  • MLN 19 protein
  • Neu protein
  • NGL protein
  • TKR1 protein

Protein level used designations for ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

GENE ID SPECIES
426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
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