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Browse our HER2 Proteins (ERBB2)

Full name:
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Proteins (ERBB2)
On are 94 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Proteins from 19 different suppliers available. Additionally we are shipping HER2 Antibodies (1529) and HER2 Kits (44) and many more products for this protein. A total of 1749 HER2 products are currently listed.
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
list all proteins Gene Name GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

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HER2 Proteins (ERBB2) by Origin

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Top referenced HER2 Proteins

  1. Human HER2 Protein expressed in Human Cells - ABIN2001858 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986 (PubMed)
    Show all 6 references for ABIN2001858

  2. Dog (Canine) HER2 Protein expressed in Human Cells - ABIN2008862 : Lai, Lemke: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. in Neuron 1991 (PubMed)
    Show all 5 references for ABIN2008862

  3. Rat (Rattus) HER2 Protein expressed in Human Cells - ABIN2009127 : Gullick, Bottomley, Lofts, Doak, Mulvey, Newman, Crumpton, Sternberg, Campbell: Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein. in The EMBO journal 1992 (PubMed)
    Show all 5 references for ABIN2009127

  4. Cynomolgus HER2 Protein expressed in Human Cells - ABIN2010107 : Codony-Servat, Albanell, Lopez-Talavera, Arribas, Baselga: Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. in Cancer research 1999 (PubMed)
    Show all 5 references for ABIN2010107

  5. Mouse (Murine) HER2 Protein expressed in Human Cells - ABIN2008225 : Tzahar, Yarden: The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. in Biochimica et biophysica acta 1998 (PubMed)
    Show all 5 references for ABIN2008225

  6. Human HER2 Protein expressed in HEK-293 Cells - ABIN2181216 : Piechocki, Wu, Jones, Jacob, Gibson, Ethier, Abrams, Yagita, Venuprasad, Wei: Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 4 references for ABIN2181216

  7. Mouse (Murine) HER2 Protein expressed in HEK-293 Cells - ABIN2181042 : Carraway, Rossi, Komatsu, Price-Schiavi, Huang, Guy, Carvajal, Fregien, Carraway, Carraway: An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for ABIN2181042

More Proteins for HER2 Interaction Partners

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. Distinct Receptor Tyrosine Kinase (show RET Proteins) Subsets Mediate Anti-HER2 Drug Resistance in Breast Cancer

  2. These results suggest that ANO1 (show ANO1 Proteins) Cl(-) channels may function as a transcriptional regulator of HER2, and ANO1 (show ANO1 Proteins) inhibitors have potential in the treatment of BCA (show BLNK Proteins) patients with resistance to HER2-targeted therapy.

  3. These findings rule out a significant deleterious effect of equivocal HER2 results. Alternative Ch17Ps may erroneously upgrade the HER2 status; therefore, they cannot be considered reliable in clinical practice.

  4. ERCC1 (show ERCC1 Proteins)-SNP in combination with mRNA ERCC1 (show ERCC1 Proteins), DPYD (show DPYD Proteins), and ERBB2 from pretherapeutic endoscopic biopsies can predict minor response to chemoradiation, as a basis for individualized therapy of advanced esophageal cancer.

  5. Ezrin (show EZR Proteins) and HER2/neu are overexpressed and coexpressed in osteosarcoma with adverse prognostic features such as high grade. Therefore, ezrin (show EZR Proteins) and HER2/neu could be potential prognostic markers and treatment targets for osteosarcoma

  6. Fulvestrant plus palbociclib was associated with significant and consistent improvement in progression-free survival compared with fulvestrant plus placebo, irrespective of the degree of endocrine resistance, hormone-receptor (show NR4A1 Proteins) expression level, and PIK3CA (show PIK3CA Proteins) mutational status. The combination could be considered as a therapeutic option for patients with HER2-negative breast cancer

  7. The lymph node status was associated with clinical stage, tumour grade, tumour histology and HER2/neu status.

  8. The results suggest that elevated serum HER2 level was associated with a clinicopathological aggressive phenotype of breast carcinoma and was related to tissue HER2 overexpression. Therefore, serum HER2 may be useful for monitoring the course of the disease and response to treatment.

  9. The main significance of this work is the discovery of EPO (show EPO Proteins) as a novel ligand for the HER2 receptor. Following HER2 activation, EPO (show EPO Proteins) induces activation of FAK (show PTK2 Proteins) and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 (show MUC4 Proteins) and the HER2 receptor

  10. In uterine serous carcinoma, 8% of patients with high HER2 intracellular domain (ICD (show GNPTAB Proteins)) had low extracellular domain (ECD (show SHFM1 Proteins)) levels (6/75 patients). In ovarian serous carcinoma, 42% of patients with high HER2 ICD (show GNPTAB Proteins) had low ECD (show SHFM1 Proteins) levels (29/69 patients).

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.

  2. Despite previous evidence suggesting that ErbB (show EGFR Proteins) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (show IARS Proteins) pathway in mouse breast cancer model.

  3. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis

  4. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)

  5. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity

  6. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (show HIF1A Proteins)-VEGF (show VEGFA Proteins) signaling axis in mediating HER2-induced tumor angiogenesis.

  7. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

  8. Data indicate that Sonic hedgehog (Shh (show SHH Proteins)) stimulate branching morphogenesis (BrM (show SMARCA2 Proteins)) and induced synthesis of mRNAs for Ptch1 (show PTCH1 Proteins) protein, epidermal growth factor (EGF (show EGF Proteins)) and receptors of the ErbB (show EGFR Proteins) receptors ErbB1 (show EGFR Proteins), ErbB2 and ErbB3 (show ERBB3 Proteins).

  9. ErbB2 receptor tyrosine kinase (show ERBB3 Proteins) in AECs was activated by annexin V (show ANXA5 Proteins), and blockade reduced the fibrotic potential of annexin V (show ANXA5 Proteins)-treated AEC-conditioned medium.

  10. Disabling of the erbB (show EGFR Proteins) pathway followed by IFNg (show IFNG Proteins) modifies phenotype and enhances genotoxic eradication of breast tumors.

HER2 (ERBB2) Protein Profile

Protein Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)
  • c-erbB2 protein
  • c-neu protein
  • CD340 protein
  • Erbb-2 protein
  • HER-2 protein
  • HER-2/neu protein
  • HER2 protein
  • mKIAA3023 protein
  • MLN 19 protein
  • Neu protein
  • NGL protein
  • TKR1 protein

Protein level used designations for ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
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