Browse our HER2 Proteins (ERBB2)

Full name:
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Proteins (ERBB2)
On are 104 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Proteins from 19 different suppliers available. Additionally we are shipping HER2 Antibodies (1583) and HER2 Kits (53) and many more products for this protein. A total of 1824 HER2 products are currently listed.
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
list all proteins Gene Name GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

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HER2 Proteins (ERBB2) by Origin

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Top referenced HER2 Proteins

  1. Human HER2 Protein expressed in Human Cells - ABIN2001860 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. in Nature 1986 (PubMed)
    Show all 9 references for 2001860

  2. Dog (Canine) HER2 Protein expressed in Human Cells - ABIN2008862 : Lai, Lemke: An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. in Neuron 1991 (PubMed)
    Show all 5 references for 2008862

  3. Rat (Rattus) HER2 Protein expressed in Human Cells - ABIN2009129 : Gullick, Bottomley, Lofts, Doak, Mulvey, Newman, Crumpton, Sternberg, Campbell: Three dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein. in The EMBO journal 1992 (PubMed)
    Show all 5 references for 2009129

  4. Cynomolgus HER2 Protein expressed in Human Cells - ABIN2010107 : Codony-Servat, Albanell, Lopez-Talavera, Arribas, Baselga: Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. in Cancer research 1999 (PubMed)
    Show all 5 references for 2010107

  5. Rhesus Monkey HER2 Protein expressed in Human Cells - ABIN2009727 : Tzahar, Yarden: The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. in Biochimica et biophysica acta 1998 (PubMed)
    Show all 5 references for 2009727

  6. Human HER2 Protein expressed in HEK-293 Cells - ABIN2181216 : Piechocki, Wu, Jones, Jacob, Gibson, Ethier, Abrams, Yagita, Venuprasad, Wei: Induction of proapoptotic antibodies to triple-negative breast cancer by vaccination with TRAIL death receptor DR5 DNA. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 4 references for 2181216

  7. Mouse (Murine) HER2 Protein expressed in HEK-293 Cells - ABIN2181042 : Carraway, Rossi, Komatsu, Price-Schiavi, Huang, Guy, Carvajal, Fregien, Carraway, Carraway: An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for 2181042

More Proteins for HER2 Interaction Partners

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. Very low density (VLD) and HER2 positivity were prognostically significant factors independent of the NPI (show NPX1 Proteins). Furthermore, the incorporation of VLD and HER2 to the NPI (show NPX1 Proteins) served to enhance its accuracy, thus offering a readily available and more accurate method for the evaluation of patient prognosis.

  2. results from this study demonstrate that MUC13 (show MUC13 Proteins) functionally interacts and activates HER2 at p1248 in PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK (show PTK2 Proteins), AKT (show AKT1 Proteins) and PAK1 (show PAK1 Proteins) as well as regulation of the growth, cytoskeleton remodeling and motility, invasion of PDAC cells-all collectively contributing to PDAC progression.

  3. correlation was found between the CEUS and ARFI characteristics of breast cancer and HER-2 expression levels. This correlation was principally reflected in perfusion defects, perforator blood flow, PI, PT, K and VTQ

  4. Our findings indicate a significant strong association of cytoplasmic Her-2/neu expression with low grades and membranous Her-2/neu expression with high grades of colorectal cancer.

  5. E-cadherin (show CDH1 Proteins) expression in breast cancers is highly comparable between briefly fixed specimens and the corresponding traditionally fixed resection specimens.

  6. Using concurrent ipsilateral samples HER2 discordance is noted in grade 2 to 3 ductal breast tumors.

  7. this study showed that HER-2 mutation was not correlated to HER-2 protein overexpression, and existing follow-up data did not show a correlation between HER-2 mutation with DFS (show FST Proteins) or OS.

  8. Data suggest that HER2-negative patients with a HER2 somatic mutation are potentially good candidates for HER2-targeted therapy.

  9. miR (show MLXIP Proteins)-3622b-5p is involved in the proliferation and apoptosis of human ERBB2-positive cancer cells via targeting ERBB2/mTORC1 signaling pathway.

  10. Downregulation of miR (show MLXIP Proteins)-30e can increase levels of MTA1 (show MTA1 Proteins) in human hepatocellular carcinoma, and furthermore promote cell invasion and metastasis by promoting ErbB2.

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. investigations revealed that NUMB (show NUMB Proteins) and NUMBL (show NUMBL Proteins) interacted with small GTPase (show RACGAP1 Proteins) Rab7 (show RAB7A Proteins) to transition ERBB2 from early to late endosome for degradation.

  2. Combined targeting of TGF-beta (show TGFB1 Proteins), EGFR (show EGFR Proteins) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.

  3. The conjugation of benzylguanine-modified auristatin F to EGFR (show EGFR Proteins)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.

  4. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.

  5. Despite previous evidence suggesting that ErbB (show EGFR Proteins) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (show IARS Proteins) pathway in mouse breast cancer model.

  6. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis

  7. Study showed that suppression of STAT3 (show STAT3 Proteins), STAT5 (show STAT5A Proteins), and STAT6 (show STAT6 Proteins) and overexpression of the proapoptotic factor STAT1 (show STAT1 Proteins), which provides p53 (show TP53 Proteins)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (show KDR Proteins) overexpression promotes neuronal survival through activation of STAT (show STAT1 Proteins)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (show STAT1 Proteins)

  8. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity

  9. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (show HIF1A Proteins)-VEGF (show VEGFA Proteins) signaling axis in mediating HER2-induced tumor angiogenesis.

  10. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

HER2 (ERBB2) Protein Profile

Protein Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2)
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2)
  • c-erbB2 protein
  • c-neu protein
  • CD340 protein
  • Erbb-2 protein
  • HER-2 protein
  • HER-2/neu protein
  • HER2 protein
  • mKIAA3023 protein
  • MLN 19 protein
  • Neu protein
  • NGL protein
  • TKR1 protein

Protein level used designations for ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
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