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ErbB2/Her2 Protein (AA 23-652)

ErbB2/Her2 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Pubmed (2 references)
Catalog No. ABIN6809903
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  • Target See all ErbB2/Her2 Proteins
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 23-652
    Origin
    • 41
    • 6
    • 4
    • 3
    • 1
    Human
    Source
    • 28
    • 9
    • 9
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    Sequence
    AA 23-652
    Purity
    >95 % as determined by SDS-PAGE.
    Endotoxin Level
    Less than 1.0 EU per μg by the LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Buffer
    PBS, pH 7.4
    Handling Advice
    Please avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
  • Turner, Kilgour, Stine, Daniele, Menegatti: "Dual-Affinity Ratiometric Quenching (DARQ) Assay for the Quantification of Therapeutic Antibodies in CHO-S Cell Culture Fluids." in: Analytical chemistry, Vol. 92, Issue 24, pp. 16274-16283, (2020) (PubMed).

    Hutterer, Polozova, Kuhns, McBride, Cao, Liu: "Assessing Analytical and Functional Similarity of Proposed Amgen Biosimilar ABP 980 to Trastuzumab." in: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, Vol. 33, Issue 3, pp. 321-333, (2019) (PubMed).

  • Target
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Alternative Name
    Her2 (ErbB2/Her2 Products)
    Synonyms
    CD340 Protein, HER-2 Protein, HER-2/neu Protein, HER2 Protein, MLN 19 Protein, NEU Protein, NGL Protein, TKR1 Protein, Erbb-2 Protein, Neu Protein, c-erbB2 Protein, c-neu Protein, mKIAA3023 Protein, wu:fv70f10 Protein, zgc:63601 Protein, erb2 Protein, erb-b2 receptor tyrosine kinase 2 Protein, ERBB2 Protein, Erbb2 Protein, erbb2 Protein
    Background
    Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2,HER-2 /neu, NEU, NGL,TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30 % of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation .
    Molecular Weight
    70.1 kDa
    NCBI Accession
    NP_004439
    Pathways
    RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
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