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Findings indicate a role of the RON tyrosine kinase receptor (show NTRK1 ELISA Kits) in pancreatic cancer and suggest RON as a potential therapeutic target.
High expression of RON is associated with drug resistance in bladder cancer.
complete loss of one or both MET and RON, as well as their overexpression, is a poor prognostic factor in patients with extrahepatic cholangiocarcinoma, probably due to the high rate of lymph-node metastasis
Study identified four novel uniquely spliced RON transcripts in small cell lung carcinoma (SCLC) and Non-SCLC cell lines.
the MST1R variant c.G917A:p.R306H is highly associated with nasopharyngeal carcinoma (odds ratio of 9.0).
Results show that under hypoxia, nuclear RON activates non-homologous end joining DNA repair by interacting with Ku70 (show XRCC6 ELISA Kits) and DNA-PKcs (show PRKDC ELISA Kits) and confers chemoresistance.
Aberrant glycosylation of the RON receptor was shown as an alternative mechanism of oncogenic activation.
Data demonstrated upregulated RON isoform expression and significant changes in splicing factor (show SLU7 ELISA Kits) expression in primary ovarian cancer suggesting a regulatory interplay of splicing factor (show SLU7 ELISA Kits) and RON alternative splicing pattern in ovarian cancer.
Activation of RON as an alternate mechanism in the development of CRPC.
the prognostic significance of MET is limited in early stage disease. MET+/RON+ patients had higher overall recurrence rates than those with the other expression patterns
this study shows that Ron is expressed in a subpopulation of macrophages during chronic inflammation induced by obesity that exhibit a repair phenotype as determined by the expression of arginase 1 (show ARG1 ELISA Kits)
Report Ron receptor-dependent gene regulation of inflammatory/anti-inflammatory gene expression in Kupffer cells during endotoxemia.
Ron knockdown further sensitized breast cancer cells to the growth inhibitory effects of vitamin D3, while constitutive activation of beta-catenin (show CTNNB1 ELISA Kits) reverted the effects of vitamin D3.
Studies demonstrate that DEK (show DEK ELISA Kits) overexpression, due in part to Ron receptor activation, drives breast cancer progression through the induction of Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.
A previously unknown function for the Ron receptor in mediating High Fat Diet-induced obesity and metabolic dysregulation.
important functional roles for Ron in inflammatory bowel diseases by regulating healing of the colonic epithelium and by controlling cytokine secretion
DC-STAMP (show TM7SF4 ELISA Kits), Siglec-15, Tspan7 (show TSPAN7 ELISA Kits) and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
Stem cell-derived tyrosine kinase plays a role in regulating macrophage recruitment and activation in the liver following acetaminophen administration and in hepatotoxicity.
studies show a critical role for the Ron receptor in the tumor microenvironment, whereby Ron loss in tumor-associated macrophages inhibits prostate cancer cell growth, at least in part, by derepressing the activity of CD8 (show CD8A ELISA Kits)(+) T cells
Identify a novel signaling mechanism by which the Ron receptor regulates acute liver failure progression.
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).
, MST1R variant RON30
, MST1R variant RON62
, PTK8 protein tyrosine kinase 8
, RON variant 21
, RON variant E2E3
, c-met-related tyrosine kinase
, macrophage-stimulating protein receptor
, soluble RON variant 1
, soluble RON variant 2
, soluble RON variant 3
, soluble RON variant 4
, friend virus susceptibility 2
, macrophage-stimulating protein receptor precursor (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase)
, receptor protein tyrosine kinase, c-met-related
, stem cell-derived tyrosine kinase
, protein tyrosine kinase 8
, tyrosine kinase receptor ron