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By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA and TrkB (show NTRK2 ELISA Kits)-receptors in cells and fibers of granular and molecular layers. TrkC (show NTRK3 ELISA Kits) was faintly detected
TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive.
report describing differential expression of proteins and mRNA for NGF (show NGFB ELISA Kits) and its cognate receptors, NTRK1 and NGFR (show NGFR ELISA Kits), in the male sex organs of rabbits
Pan-Trk immunohistochemistry is a time-efficient and tissue-efficient screen for NTRK fusions, particularly in driver-negative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma.
analysis of NTRK1 transcripts in peripheral blood cells of the patient revealed an influence of the variant on mRNA splicing. The C>A transversion generated a novel splice-site, which led to the incorporation of 10 intronic bases into the NTRK1 mRNA and consequently to a non-functional gene product.
A novel nonsense mutation and a known splice-site mutation were detected in NTRK1 in two siblings and were shown to be associated with congenital insensitivity to pain with anhidrosis.
NT3 (show NTF3 ELISA Kits) upregulates cellular proliferation, extracellular matrix protein production, and collagen deposition in human aortic valve interstitial cells through the Trk-Akt (show AKT1 ELISA Kits)-cyclin D1 (show CCND1 ELISA Kits) cascade.
NTRK1 gene fusion in spitzoid neoplasms results in tumors with Kamino bodies and were typically arranged in smaller nests with smaller predominantly spindle-shaped cells, occasionally forming rosettes.
expression levels of tropomyosin 3 (TPM3 (show TPM3 ELISA Kits)) were higher in stage III ESCC tissue compared with stage I (P<0.05). The findings of the present study identified twelve proteins, which are closely associated with ESCC invasion and metastasis, apoptosis and cell signal transduction.
Results suggest that NTRK1 oncogenic activation through gene fusion defines a novel and distinct subset of soft tissue tumors resembling lipofibromatosis (LPF), but displaying cytologic atypia and a neural immunophenotype, provisionally named LPF-like neural tumors.
This review highlights treatment options, including clinical trials for ROS1 rearrangement, RET fusions, NTRK1 fusions, MET exon skipping, BRAF mutations, and KRAS mutations.
ShcD binds to active Ret (show RET ELISA Kits), TrkA, and TrkB (show NTRK2 ELISA Kits) neurotrophic factor (show NTF3 ELISA Kits) receptors predominantly via its phosphotyrosine-binding (PTB (show PTBP1 ELISA Kits)) domain.
Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF (show NGFB ELISA Kits)-TrkA-p75NTR (show NGFR ELISA Kits) on cancer cells and their microenvironment, but also explains why NGF (show NGFB ELISA Kits) and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade.
retrograde signaling by target-derived nerve growth factor (NGF) is necessary for soma-to-axon transcytosis of TrkA receptors in sympathetic neurons.
These findings suggest that by interacting with PlexA4 (show PLXNA4 ELISA Kits), TrkA plays a crucial role in redirecting local Sema3A (show SEMA3A ELISA Kits) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (show GRIA2 ELISA Kits) localization and patterning.
proposal that KIF1A (show KIF1A ELISA Kits) is essential for the survival and function of sensory neurons because of the TrkA transport and its synergistic support of the NGF (show NGFB ELISA Kits)/TrkA/PI3K signaling pathway
As a result, overexpression of PTP (show SLC25A3 ELISA Kits)-MEG2 (show PTPN9 ELISA Kits) down-regulates NGF (show NGFB ELISA Kits)/TrkA signaling and blocks neurite outgrowth and differentiation
TrkA misfolding and aggregation induced by some Insensitivity to Pain with Anhidrosis mutations disrupt the autophagy homeostasis causing neurodegeneration.
USP36 (show USP36 ELISA Kits) actions extend beyond TrkA because the presence of USP36 (show USP36 ELISA Kits) interferes with Nedd4-2-dependent Kv7.2 (show KCNQ2 ELISA Kits)/3 channel regulation.
functional PAP (show ASAP1 ELISA Kits)(thorn) neurons are essential for the analgesic effect, which is mediated by NGF (show NGFB ELISA Kits)-trkA signaling.
Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA receptor (TrkA) through lysophosphatidic acid receptor 1 (LPA1 (show LPAR1 ELISA Kits)) binding to TrkA
adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk mouse mutant with a pain phenotype
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
high affinity nerve growth factor receptor
, tyrosine kinase receptor A
, neurotrophic tyrosine kinase, receptor, type 1
, high affinity nerve growth factor receptor-like
, tropomyosin-related kinase A
, Oncogene TRK
, TRK1-transforming tyrosine kinase protein
, TrkA neurotrophin receptor
, slow nerve growth factor receptor
, trkA proto-oncogene receptor
, neurotrophic tyrosine kinase receptor type 1
, tropomyosin receptor kinase
, alpha-tropomyosin, slow skeletal
, cytoskeletal tropomyosin TM30
, heat-stable cytoskeletal protein 30 kDa
, tropomyosin alpha-3 chain
, tropomyosin gamma