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Mouse (Murine) EPAS1 ELISA Kit for Sandwich ELISA - ABIN426617
Cockle, Rajani, Zaidi, Kottke, Thompson, Diaz, Shim, Peterson, Parney, Short, Selby, Ilett, Melcher, Vile: Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling. in Neuro-oncology 2016
findings suggest the HIF-2alpha pathway predominates over HIF-1alpha (show HIF1A ELISA Kits) signalling in neuronal-like cells following acute hypoxia
these findings demonstrated that HIF-2alpha in vselMSCs cooperated with Oct4 (show POU5F1 ELISA Kits) in survival and function. The identification of the cooperation between HIF-2alpha and Oct4 (show POU5F1 ELISA Kits) will lead to deeper characterization of the downstream targets of this interaction in vselMSCs and will have novel pathophysiological implications for the repair of infarcted myocardium.
findings indicate that HIF-2alpha increases cancer cell growth by up-regulating YAP1 (show YAP1 ELISA Kits) activity
Findings show that hypoxia inducible factor 1 alpha subunit (HIF-1alpha (show HIF1A ELISA Kits)) is phylogenetically conserved among most metazoans, whereas HIF-2alpha protein appeared later.
proteomic experiments on Normoxic Neuroblastoma (show ARHGEF16 ELISA Kits) cells to investigate HIF-2alpha downstream-regulated proteins or pathways
HIF1A (show HIF1A ELISA Kits) and HIF2A contribute to cancer stem cells survival but play different roles -HIF1A (show HIF1A ELISA Kits) being more responsible for survival functions and HIF2A for self-renewal [review].
The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha signaling may then lead to differentially modulated RCC (show XRCC1 ELISA Kits) progression in a VHL (show VHL ELISA Kits)-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha/C-MYC (show MYC ELISA Kits) signals against RCC (show XRCC1 ELISA Kits) progression.
Results suggested that the oncogenic transcription factor HIF-2alpha stabilized VHL (show VHL ELISA Kits) disease suppressor B-Myb (show MYBL2 ELISA Kits), which is also a transcription factor, by physical interaction. Some B-Myb (show MYBL2 ELISA Kits)-dependent gene expression was similarly affected by B-Myb (show MYBL2 ELISA Kits) or HIF-2alpha knockdown, suggesting that stabilization of B-Myb (show MYBL2 ELISA Kits) by HIF-2alpha may play a role in specific gene expressions.
Data suggest a common mechanism by which DNA methyltransferase1 (DNMT1 (show DNMT1 ELISA Kits)) and hypoxia inducible factors HIF1alpha (show HIF1A ELISA Kits)/HIF2alpha regulate Sprouty2 (Spry2 (show SPRY2 ELISA Kits)) transcription.
Hypoxia microenvironment in hepatocellular carcinoma up-regulates HIF2/SCF (show KITLG ELISA Kits) expression, which in turn promotes angiogenesis and HCC (show FAM126A ELISA Kits) metastasis.
Chronic activity of HIF2 in stromal progenitors impairs kidney development. Finally, these data confirm the concept that normal stroma function is essential for normal tubular differentiation.
this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection
in neurons HIF-1 (show HIF1A ELISA Kits) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (show HIF1A ELISA Kits)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke
HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.
AQP1 (show AQP1 ELISA Kits) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.
HIF1alpha (show HIF1A ELISA Kits) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.
eIF3e (show EIF3E ELISA Kits) is an angiogenesis suppressor. Silencing of eIF3e (show EIF3E ELISA Kits) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.
The regulatory connection between HIF-2alpha and VEGFR-1 (show FLT1 ELISA Kits), VEGFR-2 (show KDR ELISA Kits) and MMP2 (show MMP2 ELISA Kits).
HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (show GCG ELISA Kits) signaling.
immunostaining for HIF-1alpha (show HIF1A ELISA Kits) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a